Danny Welbeck and Jack Wilshere also remain absentees.
Costa Rica international has recovered from a groin injury and is expected to start El Clasico.
Liverpool have reduced the number of academy players from 240 to fewer than 200.
Luis Enrique will reportedly make final decision on Messi's participation in the match on 20 November.
Koscielny joined Arsenal from Ligue 1 club Lorient in 2010 and is contracted to the Gunners until 2019.
Marouane Fellaini has made six appearances in the PL this season but completed the full 90 minutes on just one occasion.
Ivorian scored the final penalty which secured the title for Chelsea.
Daniel Sturridge says it is an exciting time to be at Liverpool and play under Jurgen Klopp.
Branislav Ivanovic says Chelsea failed to react well after winning the league in May.
Louis van Gaal claims it always takes time for him to convey his philosophy to his players.
John Stones is set to be embroiled in a transfer battle involving Chelsea, Barcelona and Manchester United.
Eddie Howe has stressed that Bournemouth are not a "selling club" and will keep hold of their best players.
The Costa Rica international had loan spells at Lorient, Betis, Olympiakos and Villarreal.
Martinez is ready to remain at Atletico Madrid while Higuain will not be sold by Napoli.
Veljkovic will find another team when his contract expires at the end of the season.
Blues supporters trust survey wants managers to be 'given time to implement a plan'.
German international centre-back says the keeper has a 'bright future' in North London.
Bentaleb was taken off after just 36 minutes for Algeria while on international duty.
Spaniard returned to Melwood over the international break to have his injury treated by Liverpool.
Van Ginkel hopes a good season with Stoke will see him back in Jose Mourinho's plans.
Liverpool loanee comes through operation without complications and is expected back in 2016.
Jose Enrique last made an appearance for Liverpool in the Premier League on 17 January.
The 17-year-old joins the Old Trafford club from Fulham after impressing coaching staff.
Fifa appeal committee rejects appeal while investigation continue over Blatter payment to Platini.
Spanish news outlet Diario Vasco reported that the alleged footage shows pair "engaged in sexual acts".
Croatian has not started a game since defeat to Manchester United on 12 September.
Portuguese star says that if he has a second chance at a big club it would be different.
Sanchez played 90 minutes for the second time in four days despite worries about his health condition.
Eric Dier has been instrumental alongside Dele Alli in the midfield for Tottenham.
The Costa Rican international scored his debut Premier League goal for Arsenal against Swansea City this season.