Oscar winner Graham Moore gave the most moving speech of the night after sharing his suicide attempt at the age of 16.
Moore dedicated his Academy Award for Best Adapted Screenplay – Imitation Game – starring Benedict Camberbatch – to the lost child who feels he doesn't fit in society.
"You do. Stay weird. Stay different, and then when it's your turn and you are standing on this stage please pass the same message along," he said.
Imitation Game is based on the life of genius codebreaker, Alan Turing, (played by Camberbatch), who helped in the Second World War against the Nazis. But tragically he ended up taking his own life after being victimised for being gay during the 1950s.
Moore said: "I tried to commit suicide at 16 and now I'm standing here. I would like for this moment to be for that kid out there who feels like she doesn't fit in anywhere."
Patricia Arquette also brought people to their feet after championing the cause of equal pay and equal rights for women after picking up a gong for her Best Supporting Actress role in Boyhood.
"To every woman who gave birth to every taxpayer and citizen of this nation, we have fought for everybody else's equal rights," the mother-of two said.
"It's our time to have wage equality once and for all, and equal rights for women in the United States of America."
Julianne Moore, who won Best Actress for Still Alice, also passionately spoke about the need for Alzheimer's victims to be seen while John Legend and Common stirred the crowds including actor David Oyelowo, with their speech about the importance of democracy and human rights after being awarded for Best Original Song for Glory used in Selma.