David Moyes will begin his tenure as Manchester United manager with a trip to Swansea City in their opening game of the 2013/14 campaign.
Jose Mourinho will mark his return to the Premier League with a clash against Steve Bruce's Hull City at Stamford Bridge, while Manchester City manager Manuel Pellegrini will get his first taste of English football against Newcastle United at the Etihad.
Arsenal and Liverpool also begin their campaigns in front of their own fans, welcoming Aston Villa and Stoke City respectively.
Newly promoted Crystal Palace will welcome Tottenham Hotspur to Selhurst Park, while Cardiff City mark their return to the top flight with a visit to West Ham United.
Moyes has been handed a potentially tricky start to life at Old Trafford, taking on Chelsea (H), Liverpool (A) and Manchester City (A) within his first five games as new United boss.
The Scot will take on his former club Everton for the first time at the beginning of December when Roberto Martinez brings the Toffees to Old Trafford
Both Moyes and Pellegrini will experience the Manchester derby for the first time when City host United on the weekend of 21 September, with the return fixtures at Old Trafford taking place on the weekend of the 1 March.
Having pipped their rivals to a coveted Champions League spot on the final day of last season, Arsenal and Tottenham will resume their battle for north London dominance on the last weekend of August at the Emirates, with the Gunners returning to White Hart Lane on the weekend of 15 March.
Cardiff and Swansea will renew their hostilities in the top flight during the first weekend of November at the Cardiff City Stadium, before Malky Mackay takes his side to the Liberty Stadium on the weekend of 8 February.
Following their opener against Stoke, Liverpool will take on Aston Villa (A), Manchester United (H), Swansea (A), Southampton (H) and Sunderland (A) in August and September.
But Brendan Rodgers will be faced with a difficult proposition during the festive period, taking his side to Tottenham on the weekend of 15 December before consecutive away tips to Manchester City and Chelsea in the space of three days on the 26 and 28 December.
Andy Carroll will also return to Liverpool for the first time as a West Ham player that month when Sam Allardyce's team travel to Anfield on the weekend of the 7 December.
The campaign will end on the weekend of 11 May, where United will travel to Southampton, Manchester City welcome West Ham to the Etihad, Chelsea take on Cardiff in the Welsh capital and Arsenal travel to Norwich.
Opening Premier League fixtures (weekend beginning 17 August)
Arsenal v Aston Villa
Chelsea v Hull
Crystal Palace v Tottenham
Liverpool v Stoke
Man City v Newcastle
Norwich v Everton
Sunderland v Fulham
Swansea v Man Utd
West Brom v Southampton
West Ham v Cardiff