Itoje makes first international start in place of Joe Launchbury as Elliot Daly makes the bench.
Exclusive: former South Africa and Italy boss decided against re-applying for job after Stuart Lancaster's departure.
Daly named in Eddie Jones' 23-man squad.
Mike McCarthy, Sean O'Brien and Dave Kearney are replaced by Dave Foley, Jordi Murphy and Craig Gilroy.
Eddie Jones has 32 players to choose from for his first match as England coach at Twickenham.
Centre Ollie Devoto has not been released back to Bath, due to a slight ankle injury suffered by Alex Goode.
The 28-year-old will rejoin his former club this summer, six years after leaving for the Melbourne Rebels.
England are chasing their second victory under new coach Eddie Jones.
Duncan Taylor's late effort wasn't enough as Wales sealed a 27-23 win.
Hosts needed a late conversion from Jules Plisson to secure their second victory of the tournament.
IBTimes UK sports reporter George Flood previews the clash between Italy and England.
Wales are hoping to secure their first win of the campaign after drawing with Ireland.
IBTimes UK previews the opening match of week two of the Six Nations at the Stade de France.
IBTimes UK sports reporter George Flood previews the clash between Wales and Scotland.
IBTimes UK sports reporter George Flood previews the clash between France and Ireland.
Marko Vunipola and scrum-half Ben Youngs are among those to come in.
Duo return to their clubs, but Maro Itoje and Josh Beaumont are both included in Eddie Jones' 25-man squad.
Ospreys fly-half was replaced after just 21 minutes of Sunday's 16-16 draw with Ireland in Dublin.
Eddie Jones to confirm 23-man squad for second championship game in Rome on Tuesday.
The 36-year-old lock has been unable to recover from the injury he suffered during the World Cup.
The number eight says unity in the squad is vital after opening championship win over Scotland.
Rhys Priestland kicks 11 points as Warren Gatland's side recover from 13-0 down to draw.
Ireland are seeking to win their third consecutive Six Nations crown.
The Saracen man's man-of-the-match display earns special praise from the Australian.
George Kruis and Jack Nowell tries help England win 15-9 at Murrayfield to retain Calcutta Cup.
Jules Plisson won the game for the hosts thanks to his late penalty in the French capital.
IBTimes UK sports editor Nick Howson previews the clash between Ireland and Wales.
IBTimes UK previews the second game of the opening weekend of the Six Nations at Murrayfield.
Tim Peak intends to live tweet while the game is streamed live to the International Space Station.
IBTimes UK looks ahead to les Bleus' Six Nations meeting with the Azzuri in Paris.