Versatile defender sprained the external ligaments in his left ankle during 2-1 win over Atletico Madrid.
Wales international was replaced in the 88th minute after picking up a knock.
Champions play their first game since Claudio Ranieri's departure.
Lukaku has scored 17 goals for the Toffees this season.
Spurs are 10 points behind leaders Chelsea with 12 games left in the season.
Ibrahimovic scored twice as United beat Southampton 3-2 at Wembley.
Leicester City are without a win in the Premier League in 2017.
35-year-old Swedish striker scored brace as United beat Southampton 3-2 in final.
Real benefited from a contentious penalty decision in their 3-2 win over Villarreal.
Mane joined Liverpool in £30m deal from Southampton last summer.
Zlatan Ibrahimovic scored 87th winner as Jose Mourinho's side clinched EFL Cup final 3-2.
The Belgian internationals had to be withdrawn during Spurs' win over Stoke.
Zlatan Ibrahimovic heads home a dramatic late winner to help Jose Mourinho's side edge Wembley thriller.
Former Foxes boss Martin O'Neill has ruled himself out of the running to succeed Italian
Powerful striker has missed the club's last two matches with a groin injury.
Chelsea attempted to sign Kjaer in the January transfer window.
Pochettino's men looking to get season back on track.
Mbappé impressed in Monaco's 5-3 defeat by Manchester City in the Champions League
Keane has less than 18 months left on his current deal at Turf Moor
Mourinho confirms he will retain most of his current playing squad next season.
The Blues moved 11 points clear at the top of the Premier League table.
Visitors looking to return to winning ways after midweek defeat at Valencia.
Manchester United are looking to win the league Cup for the fifth time.
Tottenham have won their last seven games at home.
Barcelona can go top of La Liga with victory over Atletico at the Vicente Calderon.
Fellow Chile international Gary Medel wants the Gunners forward to move to the San Siro.
The Blues go 11 points clear at the summit by beating relegation-threatened Swans.
Wayne Rooney is in contention for the showcase final at Wembley after injury and illness
Wijnaldum also warned his Liverpool teammates not to be complacent against Leicester.
Chelsea are unbeaten in their last 11 games at home.