Phil Jones also features after injury, but Michael Carrick and Memphis Depay have both been left behind.
Andreas Pereira is on a season-long loan at La Liga side Granada.
Reports in Spain claim an unnamed player insulted the Barcelona forward after the game.
Kane damaged ankle ligaments during Tottenham's win over Sunderland on 18 September.
The Reds have endured a frustrating start to their season, falling well below expectations.
Reports have suggested that the Chinese Super League club are prepared to make a mammoth £80m offer.
Carroll, Diafra Sakho and Arthur Masuaku could all make long-awaited returns against Tottenham.
Injured centre-back wants to extend contract amid speculation over return to Germany.
Ferdinand says Harry Kane's return from injury will be like a new signing for Tottenham.
Tottenham are second in group E, one point behind leaders Monaco.
Granit Xhaka, Olivier Giroud and Mesut Ozil as north Londoners book place in the last 16.
United sit eighth in the Premier League table after 10 games of the campaign.
Real looking to seal qualification to Champions League round of 16 in Poland.
Pep Guardiola comes up against his former club again while Arsenal look to reach the last 16.
James Milner is expected to feature against Watford after missing Crystal Palace victory through illness.
Former centre-back urges boss to recall Michael Carrick and Henrikh Mkhitaryan ahead of Fenerbahce trip.
Mourinho hit with another misconduct charge after confrontation with referee Mark Clattenburg.
Toby Alderweireld will also remain sidelined for Champions League fixture, while Erik Lamela is doubtful.
'To have our players compete with poppies on their shirts would be particularly poignant,' said Tracey Crouch.
Young duo both played 61 minutes of an U23 Premier League draw with Everton on Monday night.
Spaniard would follow the footsteps of Bale, Vazquez, Modric and Kroos.
Klose scored 16 goals at World Cups between 2002 and 2014, putting him ahead of Ronaldo.
Schweinsteiger, 32, has previously been omitted from the United squad by Jose Mourinho.
Reds are third in the table, despite playing a series of tough fixtures.
Gerard Pique, Jordi Alba, Andres Iniesta, Jeremy Mathieu and Aleix Vidal will miss the game.
Championship club has pledged to lay on buses to go and collect vulnerable children from Calais.
Giroud scored with his first two touches against Sunderland.
United held the Reds to a 0-0 draw at Anfield on 17 October.
Spanish right-back returns to the squad after missing the La Liga win over Alaves.
Cesc Fabregas has made just one Premier League start thus far this season.