Where to watch live
Kick-off is at 8:05pm BST. Live coverage of the match is on BT Sport 2.
United come into this fixture after registering a 4-1 comfortable victory over Leicester City. The Red Devils dominated against the Premier League winners as they scored four goals in the first half.
Jose Mourinho made several changes to the starting lineup, including dropping Wayne Rooney on the bench. United scored three of their four goals from corners, delivered by left-back Daley Blind, who was playing in place of injured Luke Shaw.
The performance against Claudio Ranieri's side was lauded by pundits. Summer signing Paul Pogba scored his first goal for United and was named the Man of the Match. He is unlikely to start for the Europa League clash.
In the last European fixture, United suffered a 1-0 defeat at the hands of Feyenoord. The former Real Madrid and Chelsea manage will be keen on helping his side seal their first win in the competition on Thursday.
It is for the first time that Luhansk are featuring in the group stages of the Europa League. In the first fixture of the competition, they were forced to settle for a 1-1 draw at the hands of Fenerbahce.
Yuriy Vernydub will be hoping his side can pull off an upset by beating the Premier League giants in their own backyard when Luhansk take on United on Thursday evening.
What managers say
Jose Mourinho: "I was completely convinced to play with him [Rooney] from the beginning [on Thursday] but with his situation in the last couple of days I am not sure. With the situation you [the media] create for him, he really can't afford to have a performance that is not really good. I am here to protect him and not put him in difficult situations."
Yuriy Vernydub: "There's no need to be evasive. We understand that Manchester United are a world class brand."
Betting Odds (betfair)
- Manchester United: 1/8
- Draw: 13/2
- Zorya Luhansk: 28
Possible XI: Romero; Darmian, Bailly, Smalling, Rojo; Carrick, Herrera, Schneiderlin; Depay, Ibrahimovic, Mata