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Real Madrid will look to reignite their La Liga title hopes by beating Barcelona at the Nou Camp on 2 April.
Where to watch live
Kick-off is set for 7.30pm BST. The game will be broadcast live on Sky Sports 2 HD.
Barcelona were held to a 2-2 draw at Villarreal in their last league outing — a result that stretched their unbeaten run in competitive fixtures to 39. The Catalan giants boast a nine-point lead over second-placed Atletico Madrid and a 10-point advantage over third-placed Real Madrid.
Defender Jeremy Mathieu is sidelined after suffering a knee injury on international duty but Ivan Rakitic, Sergio Busquets and Andres Iniesta are all available after recovering from knocks.
Real Madrid's 4-0 win over Sevilla was their fifth straight victory in all competitions. The capital club will be out for revenge after they were beaten 4-0 by Barca in the reverse fixture in November.
Sergio Ramos pulled out of international duty for Spain with a back complaint but is expected to start at the Nou Camp.
What managers say
Luis Enrique: "We were close to getting three points [against Villarreal] but we also nearly lost, so I'm positive. Every point we gain on the team chasing us is fantastic. Once the game began, our players understood how the game was going to be. We weren't distracted, but Villarreal have a great understanding."
Zinedine Zidane: "[El Clasico] a significant game because it's a special match. We have to continue improving. It's better to go into it on the back of a win. We've shown a lot with tonight's performance. We know that we're ready. It'll be a great game between two great sides."
- Barcelona (all competitions): DWWWW
- Last result: Villarreal 2-2 Barcelona
- Real Madrid (all competitions): WWWWW
- Last result: Real Madrid 4-0 Sevilla
Betting odds (Betfair)
- Barcelona win: 6/10
- Draw: 18/5
- Real Madrid win: 9/2
Barcelona possible XI: Bravo; Alves, Pique, Mascherano, Alba; Rakitic, Busquets, Iniesta; Messi, Suarez, Neymar
Real Madrid possible XI: Navas; Danilo, Pepe, Ramos, Marcelo; Kroos, Casemiro, Modric; Bale, Benzema, Ronaldo