Where to watch live
Kick-off is set for 8pm BST. Live coverage of the game is available on Sky Sports 1 and Sky Sports HD 1.
Crystal Palace have a host of injury troubles, with almost 11 players likely to miss the game. However, Joe Ledley is expected to return to action following the birth of his child, for which he was on leave. James McArthur is doubtful for the game with a back problem, while Scott Dann, Patrick van Aanholt and James Tomkins are unavailable.
Palace have been in brilliant form in recent weeks, winning three of their last four games, including one against Chelsea, which has kept out of the bottom three. However, Sam Allardyce, who has never been relegated in his lengthy spell as a manager in the league, will have to get his team back in prime form in order to beat the drop, as they are only three points ahead of Swansea City in 18th, albeit having played two games less.
Meanwhile, Arsenal have a few injury worries of their own, especially for goalkeeper, where Emiliano Martinez will resume services between the sticks for the Gunners as Petr Cech and David Ospina are both out with respective calf and back injuries. Santi Cazorla is out for the rest of the season while Francis Coquelin returns to the squad after missing out against West Ham with a personal issue.
The Gunners got back to winning ways against the Hammers with a comfortable 3-0 victory, their first win since beating Hull City in February. Mesut Ozil, Theo Walcott and Olivier Giroud got their names on the scoresheet, with Martinez also keeping a clean sheet, keeping the Gunners in the race for a top four spot.
What managers say
Sam Allardyce on Christian Benteke: "He's got his goalscoring head back on again. He's got two in the last two games and is going to be very important for us. It takes some overcoming when you get knocked like that but he's picked himself up by the goals he scores. His confidence is back, and the more he puts the ball in the back of the net for us the more chance we have of picking up the points that will make us safe. The boost for the players is that we can get points against the big clubs, and we've just proven that by beating Chelsea. We have shown that no matter who it is we can get a result."
Arsene Wenger: "The speed of our passing [was there] in the heart of the game. It is not only the quality of the passing but the speed of our passing that is needed for the way we want to play, because we have quick strikers so it's important that we feed them quickly. On that front, the quality, the speed of the decision making becomes very important. The win of Crystal Palace at Chelsea is in the continuity of what we have seen in the Premier League since the start of the season -- surprising results because the difference between the teams has become shorter and smaller, so anything can happen in any game. We know we have to play at our best to win."
- Crystal Palace win: 15/4
- Draw: 29/10
- Arsenal win: 4/5
Possible XI: Hennessey, Ward, Delaney, Sakho, Schlupp, Milivojevic, Ledley, Zaha, Puncheon, Townsend, Benteke.
Possible XI: Martinez; Bellerin, Gabriel, Mustafi, Monreal; Oxlade-Chamberlain, Coquelin; Walcott, Ozil, Iwobi; Sanchez.