Bath winger Semesa Rokoduguni will make his England debut in the opening QBE autumn international against New Zealand.
Dave Attwood will start in the second row after the birth of his first child on Tuesday while Brad Barritt returns to the centre to partner Kyle Eastmond.
Anthony Watson and George Kruis are in line for their first international appearances after being confirmed on the England bench for the first of four autumn fixtures less than a year before the World Cup.
"I am delighted for Roko," said coach Stuart Lancaster. "Wing is an extremely competitive position but he has pushed himself forward with his form this season and it's great to be able to give him this opportunity.
"The same is true with Anthony Watson and George Kruis. I am sure they will contribute should they come off the bench.
"Dave Attwood has had an eventful week with the birth of his first child and congratulations to him and his fiancée Bridget. He's back with us now and will be ready to go for Saturday."
Meanwhile, New Zealand coach Steve Hansen has recalled a host of experienced players for the second match of his side's northern hemisphere tour but there is no place for Dan Carter in the match-day squad.
Carter made a cameo appearance in the 74-6 win over the USA last weekend but will not be risked at Twickenham as he continues to recover from injury, with Aaron Cruden preferred at fly-half. Lock Brodie Retallick and winger Julian Savea both return.
"This Test match is a great opportunity to once again experience the atmosphere of Twickenham and to lay down a marker of where we are currently at in relation to our opponents, England," said Hansen.
"We are extremely excited about this challenge and looking forward to it immensely. Having played England already three times this year, at the beginning of our season, and again having the opportunity to play them at the end of season, will tell us a lot about how much our game has progressed."
England: 15. Mike Brown, 14. Semesa Rokoduguni, 13. Brad Barritt, 12. Kyle Eastmond, 11. Jonny May, 10. Owen Farrell, 9. Danny Care; 1. Joe Marler, 2. Dylan Hartley, 3. David Wilson, 4. Dave Attwood, 5. Courtney Lawes, 6. Tom Wood, 7. Chris Robshaw (c), 8. Billy Vunipola
Replacements: 16. Rob Webber, 17. Matt Mullen, 18. Kieran Brookes, 19. George Kruis, 20. Ben Morgan, 21. Ben Youngs, 22. George Ford, 23. Anthony Watson,
New Zealand: 15. Israel Dagg, 14. Ben Smith, 13. Conrad Smith, 12. Sonny Bill Williams, 11. Julian Savea, 10. Aaron Cruden, 9. Aaron Smith; 1. Wyatt Crockett, 2. Dane Coles, 3. Owen Franks, 4. Brodie Retallick, 5. Samuel Whitelock, 6. Jerome Kaino, 7. Ritchie McCaw (c), 8. Kieran Read
Replacements: 16. Keven Mealamu, 17. Ben Franks, 18. Charlie Faumuina, 19. Patrick Tuipulotu, 20. Liam Messam, 21. TJ Perenara, 22. Beauden Barrett, 23. Ryan Crotty