Anticipation ahead of the first Manchester derby of the season has reached fever-pitch, with the fixture being the first time City boss Pep Guardiola and United manager Jose Mourinho will face each other in over three years.
Both clubs have a 100% record heading to the clash, with City sitting above United on goal difference on the Premier League table.
Silva scored twice for Spain in their World Cup qualifier against Belgium and is in excellent form heading into the Old Trafford showdown.
"It's going to be a very beautiful game. The two teams arrive to this game having taken good results and after making wholesale changes in every sense," he was quoted as saying by Spanish daily Marca.
"We've started the season very well and it should be a great game. But we won't be playing for a draw. We will go out to win the match."
United are unbeaten in their last three games against their city rivals, but Silva insisted that the statistic would not dissuade City from going for three points at Old Trafford.
"It's a ground where in the last few years things have gone okay for us. We know they are a very difficult rival – but we won't settle for a draw," the 30-year-old said.
Guardiola has a dominant head-to-head record against Mourinho: seven wins, six draws and only three defeats.
The last time the two managers – who have both won two European Cups each – faced each other was in the Uefa Super Cup in 2013.
Guardiola's Bayern beat Mourinho's Chelsea 5-4 on penalties after a 2-2 draw in Prague.
City's last win at Old Trafford was a 3-0 success that came during David Moyes's ill-fated United reign in 2014.