Midtjylland, who haven't played a competitive game in two months, are in control of this tie. A truly abysmal performance from United that ranks alongside the one away to Olympiakos under David Moyes in 2014 as their worst in recent memory.

FULL TIME: Midtjylland vs Manchester United

Sisto pings a poor effort into the wall and Pereira breaks forward with promise. Pity we are out of time.

Midtjylland have a free kick just outside the box as Smalling holds back Ureña. Yellow card for the United centre half, and this free kick should be the last chance of the game.

The corner is met by Carrick, but his header is a poor one and the balls sails over. Four minutes of time added on.

United venture foward now with Pereira trying to jink his way into a shooting position but can't find one. He plays it wide to McNair who wins a corner.

Less than five minutes remaining here, United look to have no interest in scoring. The dismal performance is summed up again as Herrera pings a pass out to Lingard whose attempt to control it is hopeless.

Midtjylland showboating now, United offering absolutely nothing.

Mata was hauled off just after that goal, by the way, replaced by Andreas Pereira.

More laughs from United as Smalling and Romero can't make up their mind who is claiming a through ball, allowing Kadlec in to drag a shot just wide of the target.

Oh Juan. An absolutely pitiful attempt from Mata to try and win the ball from Onuachu on the edge of the box is the latest in a string of embarrassing moments for Louis van Gaal's side. The substitute steps away from the Spaniard easily and arrows a fine effort into the bottom corner.

Goal! Midtjylland 2-1 Manchester United (Onuachu)

15 minutes to go in this game and Midtjylland are the side looking the far more dangerous at the moment.

Schneiderlin, just off the bench, tries to hook a ball into the box but it is charged down by Kadlec, who keeps the Frenchman under pressure and wins the ball too easily to spring forward. They just about recover the ball but United are offering absolutely no protection to their defence at the minute, each time Midtjylland come forward they do so almost unchallenged.

Hansen plays a ball forward for Kadlec who tries for goal from 20 yards out, but it's wide. Carrick and Herrera might as well not be out there, Midtjylland are strolling through midfield with ease on each occasion.

United almost caught out as Herrera - who has having a dreadful game - loses the ball on the half way line, allowing Onuachu to race forward. He plays it wide to Ureña who threads a pass across for Sisto, who again cuts in onto his right and tries to curl one towards the far corner, but his radar is off this time.

United are 20 passes in to a move when Love tries to thread a precise one through down the inside right but goalkeeper Andersen is always the favourite to reach it first.

Sergio Romero saves United again! Just off the bench, Onuachu meets a wonderful cross from the right with a header that seems destined for the top corner, only to see the Argentine goalkeeper spring across goal and claw it out. The ball breaks loose momentarily, but Romero is alive to it and follows up his terrific first save by batting the ball clear to safety.

United have dominated the last 10 minutes or so; in that time they've hit the bar and had two very decent chances to go back ahead.

Another neat move sees Love drive forward, finding Memphis who lays an inviting one off for Herrera to run onto. It's from a tough angle, but you would expect the Spaniard to hit the target. He doesn't. Not even near. Miles away.

Lingard hits the bar! Memphis pings an outside-of-the-boot out to Herrera who dinks in a wonderful ball that Lingard meets with a volley. It's a decent connection, unlike his last few efforts, but he can't keep it down and it cracks off the woodwork.

Great chance for Mata as Memphis picks him out at the near post but the Spain international plants his free header to wrong side of the post. Another really poor effort.

Herrera loses the ball again inside his own half, allowing the home side to pick out their dangerman Sisto. He cuts in onto his right foot menacingly again but this time his vicious shot his straight at Romero.

Sublime work from Martial who cuts in from the left, slipping past two defenders before teeing up Lingard on the edge of the box. He has plenty of time to wind back a shot but it is an absolutely awful effort, scooping it off target.

And United get us back underway for the second half.

An odd half in Denmark draws to a close. United have looked shambolic in defence so far - not the fault of Sergio Romero, mind - but they have an away goal after Memphis Depay's scrapper opener.

HALF TIME: Midtjylland 1-1 Manchester United

Midtjylland are level! Carrick loses the ball, inviting the tricky Sisto to race forward. Herrera tries to keep on him and perhaps should do better as he is easily beaten on the edge of the box. Sisto keeps his composure, however, and drills a fine right-footed effort past Romero.

Goal! Midtjylland 1-1 Manchester United (Sisto, 43)

United should be 1-0 down but now they find themselves ahead! From that previous corner, Martial loses the ball on the edge of the 18-yard area and the home side are clean through on goal from the half way line! Vaclav Kadlec leads the attack with just Romero to beat, but with a man to his right, goes for goal, only to see his meek effort saved by the legs of Romero.

56 seconds later, Memphis is just outside the six yard area and recovers after a slip to prod a cross from the right towards goal, taking a touch off the goalkeeper in the process. Martial was mighty tempted to get a touch on it to make sure, but wisely left it, having been stood in an offside position.

Goal! Midtjylland 0-1 Manchester United (Memphis Depay, 40)

Memphis wins a free kick out on the left and takes it him, looking for the near post, drawing a decent save from Andersen.

Some slick build-up from United sees Blind whip a fine ball into the box but Martial makes an awful mess of it, failing to get any real connection on the ball. Mata tries to reach the loose ball but it is cleared.

Half an hour gone here, you'll be shocked to hear it hasn't been a classic.

Another United attack breaks down after Memphis plays a woeful ball on for... someone... that rolls out of play.

Olsson runs at the heart of United's defence and causes a moment of panic until Smalling sticks out a decisive boot to intercept.

Anthony Marital cuts into the box onto his right foot but falls to the ground far too easily under pressure from his marker. Appeals for a penalty are quickly dismissed.

Great chance for Smalling! Blind lifts a beauty of a cross in towards the far post that Smalling is tracking all the way. He is free as he connects with it but can only head it across goal, with no one following it up.

Martial shows brilliant balance to roll one challenge and cut back inside from the right but his shot on goal is well blocked. United have another corner.

The resulting corner comes in towards Ander Herrera but the midfielder nuts his effort well over.

Hansen again duels with Memphis down the left. The Dutchman jinks past him at the first attempt but delays his cross a second too long, allowing the defender to make the block.

Sisto looks to have the better as he jinks inside Smalling but the United centre half wins it back on the second attempt, despite appeals for a foul.

United do look dangerous on the counter and are operating in acres of space when they do find space. Martial this time drives forward before sliding it wide to Memphis, but he is easily blocked off by Rømer who ends the move.

Good save from Romero! Free kick specialists Midtjylland lift one into the box towards Hansen, who has lost Blind to head one on goal. The Argentine gets a strong hand to his effort to make a fine reaction save.

Blind rolls the corner into Mata with the Midtjylland defence sleeping, but the Spaniard's effort is saved by Andersen.

Great counter from United as Lingard threads a ball through for Martial but there is too much on it for the Frenchman to get real control of the shot. He manages to force it on target anyway, forcing a corner.

Now Herrera is off to receive treatment with a bloodied nose. They are dropping like flies.

Chris Smalling was made to trot off for a quick bit of treatment. He's fine moments later but no official won't let him back on the pitch! After a few minutes, he's eventually waved back on. Not sure what happened there, both the referee and his officials were looking straight at the United defender but chose to ignore him.

Hansen chucks a monster of a throw-in into the United box that just about evades everyone. It's picked up on the otherside by Sisto who lifts another cross in but Memphis shields it well and is fouled by Rømer.

Bit of early pressure on the United goal is relieved by Memphis who races forward down the other end of the pitch. He prods a pass into Martial from the edge of the box but the Frenchman loses his footing and the home side can clear.

And Midtjylland get us underway.

Just a few minutes until kick off; how much will that late change affect United? An already shaky back-line without the presence of De Gea behind it now looks a whole lot shakier.

Midtjylland team to face Manchester United.

Make that 13-man injury list a 14-man one, then. De Gea is out of tonight's match. Confirmation from United:

United will start with no goalkeeper on the bench, then.

BREAKING: Sergio Romero will start in place of David de Gea, who suffered a twisted ankle in the warm-up.

De Gea hasn't emerged from the dressing room after heading down for some treatment. BT Sport are now suggesting he should be okay to start this evening. Sergio Romero waits in reserve in case.

A twisted ankle for De Gea? Oh dear.

De Gea also took his gloves off as he limped off the pitch just then. HUGE thing to do 15 minutes from kick off.

David de Gea doesn't look too comfortable at the moment, the Spaniard is moving gingerly after pulling something in the warm-up.

Here is what Louis van Gaal had to say about the club's growing injury list earlier this week.

We have 13 players injured and Wayne is one of them. You can never say [how long he could be out for]. He has a knee problem so we have to wait and see. He scores a lot of goals so he is very important for us. We know that but we have to cope with that."

For all United's concerns at the back, their front six looks fairly promising ahead of kick off. Michael Carrick and Ander Herrera in midfield in front of a fluid four of Juan Mata, Jesse Lingard, Memphis Depay and Anthony Martial has the potential to cause lots of problems for the home side this evening.

Midtjylland vs Manchester United is one of seven games kicking off in around 40 minutes or so. Fiorentina host Premier League title challengers Tottenham Hotspur in one of those, you can keep up to date with that game right here.

You will probably recall Manchester United's last jaunt in this competition. Sir Alex Ferguson's side edged past Ajex despite suffering a 2-1 loss to the Dutch giants at Old Trafford, before they were positively schooled by Marcelo Bielsa's Atheltic Bilbao over two legs in the round of 16.

Not familiar with FC Midtjylland? Hang your head in shame. If that's you, here is our everything-you-need-to-know guide to the Danish champions.

Paddy McNair has started just two games for United this season, once at right-back in the 1-1 draw with Leicester and at centre-half in the 2-1 defeat to Bournemouth.

Might this have been a game for Andreas Pereira, perhaps? The Brazil Under-20 international hasn't started a game since October, but once again he sits among the subs.

Anthony Martial will start through the middle for United this evening, flanked either side by Memphis Depay and Jesse Lingard with Mata occupying his favoured role in the middle.

United have a 17-year-old, an 18-year-old and two 20-year-olds on their bench, with Will Keane the old man of the United academy contingent at the grand old age of 23.

Ander Herrera is also back in the starting XI as United make four changes to the side that lost to Sunderland.

BREAKING: Donald Love is handed his first start for United at right back with Daley Blind slotting in at left-back. Paddy McNair drops in alongside Chris Smalling at centre-half. Memphis Depay comes in for the injured Wayne Rooney.

United team to face Midtjylland: De Gea, Love, Smalling, McNair, Blind, Herrera, Carrick, Lingard, Mata, Memphis, Martial.

Subs: Romero, Poole, Riley, Pereira, Schneiderlin, Weir, Keane

TEAM NEWS: Manchester United

United were already without Marouane Fellaini, Phil Jones, Adnan Januzaj, Guillermo Varela, Bastian Schweinsteiger, Marcos Rojo and Antonio Valencia ahead of the defeat to Sunderland – with Ashley Young and Luke Shaw long-term absentees.

Since then, they have also lost Matteo Darmian to a dislocated shoulder, Cameron Borthwick-Jackson to illness and Wayne Rooney to a knee injury that could rule him out for up to two months. All in all, Louis van Gaal is without 13 members of his squad, with youngsters Donald Love, Regan Poole, James Weir and Joe Riley drafted into the travelling squad.

Love, who came off the bench to replace the injured Darmian on Saturday, is likely to start at right back, with United without a single fit senior full-back among their ranks.

United's return to European football comes a day later than they would have liked. Instead of a glamour tie on Tuesday or Wednesday night with one of Europe's elite, they will start getting used to dreaded Thursday night games with a trip to Denmark.

FC Midtjylland have already come up against English opposition this season, ending Southampton's run in this competition before it really got started in a play-off tie last summer. Their chances of causing another upset this evening will be significantly helped by United's desperate injury list, that sees them without 13 members of their squad this evening.

A 2-1 defeat to Sunderland on Saturday 13 February was another devastating blow to United's chances of closing the gap on the sides above them with Louis van Gaal admitting post-match the club's best chance of qualifying for next season's Champions League now lies in winning the Europa League. Given the quality of some of the sides they could have drawn in this round of 32, United can't afford to mess this up at this early stage.