Stuart Lancaster will hand first Rugby World Cup starting appearances to four players in England's final Pool A game against Uruguay on Saturday 10 October.
After their hopes of qualifying for the knockout stages of the competition ended with defeat to Australia, Stuart Lancaster has made nine changes to his match day squad for the clash.
Henry Slade and Jack Nowell come in at outside centre and wing while Alex Goode and Danny Care will also make their make their first appearances in the competition at full back and scrum half, respectively. George Ford returns at fly half while Owen Farrell comes in for injured Saracens clubmate Brad Barritt.
Elsewhere, James Haskell and Nick Easter replace Tom Wood and Ben Morgan in the back row while Sam Burgess has been left out of the match day squad completely.
"This is an opportunity for us to finish the tournament with a strong performance against Uruguay and a chance for young players such as Jack Nowell and Henry Slade to play in a World Cup," Lancaster said.
"We owe it to ourselves and the supporters who have been brilliant throughout. This is an important game for rugby in the north of England and we want to give those people who have been looking forward to this game something to cheer about."
England team to face Uruguay: Alex Goode, Anthony Watson, Henry Slade, Owen Farrell, Jack Nowell, George Ford. Danny Care; Mako Vunipola, Tom Youngs, Dan Cole, Joe Launchbury, Geoff Parling, James Haskell, Chris Robshaw, Nick Easter.
Replacements: Jamie George, Joe Marler, David Wilson, George Kruis, Tom Wood, Richard Wigglesworth, Jonathan Joseph, Mike Brown.