Ryan Giggs will take interim charge of Manchester United until the appointment of a permanent successor to David Moyes, the club have confirmed.
Giggs, part of the club's backroom team under Moyes, will lead United in their final four league games starting against Norwich City this weekend.
The 40 year old is both the most decorated player of United's history and the club's highest appearance maker.
A club statement read: "Following the departure of David Moyes as manager, Manchester United has announced that Ryan Giggs, the club's most decorated player, will assume responsibility for the first team until a permanent appointment can be made.
"The club will make no further comment on this process until it is concluded."
The former Wales international continues to study for his UEFA Pro coaching license having made up part of Moyes' backroom team which also includes Phil Neville, but a role at the helm at Old Trafford represents his first making coaching position.
Alongside Netherlands coach Louis van Gaal and Atletico Madrid boss Diego Simeone, Giggs is among the contenders to permanently replace Moyes ahead of next season and has four matches in order to stake his claim for the role.
Borussia Dortmund boss Jurgen Klopp has ruled himself out of replacing Moyes by committing himself to the Bundesliga club.
United face three successive home games against Norwich, Sunderland and Hull City before travelling to Southampton on the final day of the campaign.
Moyes' departure comes 10 months into his six-year contract at the Theatre of Dreams and follows United's 11th league defeat of the season against Everton which mathematically ended hopes of qualifying for the Champions League.
A foray to the quarter final of the Champions League against Bayern Munich gave Moyes a stay of execution at Old Trafford, but with United facing their worst top flight league finish for 23 years, the Glazer family have opted for change ahead of the new term.