Jeremy Corbyn will make a fresh appeal to Brexit voters as part of the left-winger's New Year message, to be released on Friday morning (30 December).
Corbyn, who was re-elected Labour leader with an increased majority in September, is expected to argue that the Leave campaign won the referendum because of disillusionment with the political class and the EU.
"2016 will be defined in history by the referendum on our EU membership", he will say. "People didn't trust politicians and they didn't trust the EU.
"I understand that. I've spent over 40 years in politics campaigning for a better way of doing things, standing up for people, taking on the establishment, and opposing decisions that would make us worse off."
The Labour leader will also argue that decisions made in Westminster are "making people's lives harder", referencing the social care system in England and Wales, low pay and zero-hours contracts.
Corbyn will add: "Labour was founded to stand up for people and we founded the institutions that do that day in, and day out, like our NHS. We are the party that listens to you and makes Britain better. Let's do that, together, in 2017."
The comments will come after Corbyn was dealt another blow, with Jamie Reed's resignation as Labour MP for the Cumbrian seat of Copeland. Reed, a critic of Corbyn, secured a majority of just over 2,500 votes at the general election.
The by-election for the north of England constituency will be an early test in 2017 for Corbyn. The city region mayoral elections of 2017, including Greater Manchester, West Midlands and Greater Liverpool, will provide another marker for Labour's popularity in May.
But the political year is expected to be dominated by the UK's split from the EU. Theresa May has promised to invoke Article 50, the mechanism to split from the bloc, by the end of March 2017.
The Supreme Court will rule in January over whether MPs need to have a vote on triggering the mechanism. Labour have promised not to block a Brexit, but the party has said they will seek an amendment to an Article 50 bill if the government does not unveil a "meaningful" plan.
"A Brexit that protects the bankers in the City and continues to give corporate handouts to the biggest companies is not good enough," Corbyn will say.
The latest national opinion poll from Opinium for The Observer, of 2,000 voters between 13 and 16 December, put the Conservatives seven points ahead of Labour (38% versus 31%).
Full transcript of Corbyn's New Year message
I think it's fair to say, that 2016 is a year that will live long in all our memories.
It saw 12 months of enormous change not just in Britain but the world.
But the New Year gives all the opportunity to start afresh.
One of the best things about my job as Leader of the Labour Party is meeting some fantastic people all over the country.
But every day I see the political system letting down the people of this country; how decisions made in Westminster are making people's lives harder.
Whether that's elderly people not receiving the care at home they deserve, putting huge strain on them and their family, or whether it's the people waiting longer in A&E or on trolleys because our National Health Service and social care system is at breaking point, despite the best efforts of the wonderful and dedicated staff.
Whether it's the homeless families who are being priced out of a housing market that only works for the few. This Christmas, 120,000 children didn't have a home to call their own. That's scandalous. And it's damaging those young people's formative years. Our children also need a first class education for everyone, not just for a privileged few.
As well as insecure housing there is massive insecurity at work too. Millions of people can't plan their lives because whether on temporary or zero hours contracts they don't know what job or what hours they'll have from day to day, week to week or month to month. And for many, pay is so low that it doesn't make ends meet.
2016 will be defined in history by the referendum on our EU membership. People didn't trust politicians and they didn't trust the European Union.
I understand that. I've spent over 40 years in politics campaigning for a better way of doing things, standing up for people, taking on the establishment, and opposing decisions that would make us worse off.
We now have the chance to do things differently. To build an economy that invests and works for everyone across all our nations and regions.
Labour accepts and respects the result of the referendum. We won't be blocking our leaving the European Union, but we won't stand by.
Those in charge today have put the jobs market, housing, the NHS and social care in crisis. We can't let them mess this up. It's about everyone's future.
A Brexit that protects the bankers in the City and continues to give corporate handouts to the biggest companies is not good enough.
Labour was founded to stand up for people, and we founded the institutions that do that day in, and day out, like our NHS. We are the party that listens to you and makes Britain better. Let's do that, together, in 2017.