Where to watch
Kick-off is at 3pm BST. Catch the highlights on Match of the Day 2 on BBC One and BBC One HD at 10:20pm BST.
United bounced back following their 4-0 defeat at the hands of Chelsea in the league by defeating Manchester City 1-0 in the fourth round of the EFL Cup at Old Trafford. They have now progressed to the quarter-final and will face West Ham United at home.
Pep Guardiola's side failed to register even a single shot on target against the Red Devils, who had Daley Blind and Marcos Rojo as the central defenders. This should boost their confidence as they look to extend their EFL Cup and the Europa League form to the league fixtures.
Jose Mourinho has admitted that it is time for his side to pick up points in the Premier League fixtures as they have only one win in the league since the end of August. A victory on Saturday will boost their chances of inching closer towards the top four clubs.
Burnley, on the other hand started the season on a brighter note by registering a 2-0 win over Liverpool, despite the Reds dominating the game with possession. They are also high on confidence as they defeated Everton 2-1 in the last fixture.
However, Sean Dyche has seen his side suffer defeats in the away fixtures as they have lost all of their three fixtures. In addition to this, they have conceded nine goals and managed to score only one in the process.
What managers say
Jose Mourinho: "Micky [Mkhitaryan] needs time to become the top player he can be. Of course we believe in him and of course we believe that sooner or later there will be no problem."
Sean Dyche: "I look at the manager, the club, the players they've got and they're still a super strong group of people operating at the highest level. I'd be very surprised if this group of players is not still a very, very strong group and a group to be reckoned with over the course of the season."
Betting Odds (betfair)
- Manchester United: 2/11
- Draw: 6
- Burnley: 18
Possible XI: De Gea; Valencia, Smalling, Blind, Shaw; Carrick, Herrera; Mata, Pogba, Rashford; Ibrahimovic
Possible XI: Heaton; Lowton, Keane, Mee, Ward; Gudmundsson, Marney, Hendrick, Kightly; Arfield; Vokes