Manchester United are set to be without Phil Jones, Michael Carrick and Eric Bailly for the Champions League clash with FC Basel after the trio missed training ahead of the trip to Switzerland.
Jones, who took six pain-killing injections to play for England against Brazil last week, is suffering from a thigh problem while Bailly remains out after missing the win over Newcastle United with an undisclosed problem.
Carrick meanwhile is reportedly suffering from a mystery illness which has surfaced amid his recovery from a calf problem. The 36-year-old, who is in the final year of his contract with United, has not played a single minute in the Premier League this season.
But they were the only absentees from United's final session before they set off for their fifth Champions League group match. Jose Mourinho's side only need a point to guarantee themselves passage to the last 16 after winning each of their opening four games.
Mourinho will address the media at 5pm GMT when he is expected to confirm that the three players will miss the game.
Zlatan Ibrahimovic is in line for the first United start of his second coming with the three-time European Cup winners, after making a 13-minute cameo appearance against Newcastle on his return from a seven-month long absence due to a knee injury.
Marcos Rojo may also be recalled after fully recovering from a knee problem of his own, while Paul Pogba could be rested as he builds towards achieving full match sharpness. The France international played 70 minutes of the 4-1 win over Newcastle, contributing a goal and an assist, after two months out with a hamstring injury.
Henrikh Mkhitaryan will be bidding for a recall after being left out of the United squad at the weekend, amid reports Mourinho has become exacerbated by the Armenia international.
The Sun understand Mkhitaryan - who has travelled to Switzerland for the fixture - is fighting for his career at Old Trafford just 16 months on from joining from Borussia Dortmund.
Mkhitaryan has only complete a full 90 minutes twice in his 16 appearances this season and his declining fortunes mirror his troubles last term, when he was criticised by Mourinho for his lack of fitness.
It remains to be seen whether Mkhitaryan can regain his place in the United team, or if he is forced to wait until the resumption of the Premier League season to reignite his career.