Where to watch live
Kick-off is at 4pm BST. Live coverage is on Sky Sports 1 and Sky Sports 1 HD. Radio commentary of the game will be available on BBC Radio 5 Live. Catch the highlights of the game on Match of the Day 2 on BBC One and BBC One HD at 10:30pm BST.
Arsenal suffered a 2-0 defeat at the hands of Tottenham Hotspur in the north London derby at White Hart Lane. Dele Alli was on target for Spurs in the second half before Harry Kane doubled the lead, minutes later from a spot kick.
The Gunners have had mixed results in the Premier League, where they have failed to gather momentum since the end of January. They have failed to win more than two league matches in a row in this calendar year.
Arsene Wenger will be hoping his side can bounce back from the defeat against Tottenham when they face the Red Devils. A defeat could make their season even more disappointing, with only the FA Cup to fight for.
United enter this tie after registering a narrow 1-0 victory over Celta Vigo in the first leg of the Europa League semi-final. Marcus Rashford's brilliant free-kick helped the Premier League side to take the lead in Spain.
The Red Devils have had a very good defensive record in recent times, conceding only four goals in the last 10 matches played across all competitions. They will be looking to further improve their defensive record against Arsenal.
Jose Mourinho will be hoping his side can seal three points against the Gunners in the league tie on Sunday. A victory will be a massive boost for United for their upcoming fixtures against Celta and Tottenham.
What managers say
Arsene Wenger: "We focus on our performance. I don't know what Man Utd will do. We know anyway they have a massive squad with quality players and only a top performance will get us the win we want. No, the only advantage we can give is to focus on ourselves, not a weaker Manchester United. No matter who plays, they will have a strong team out. What I want is that my team turns up with a strong performance on Sunday. Granit Xhaka is still out. Mustafi is back in normal training, that's basically it. Ospina is fully fit, Lucas Perez is back in training but will miss the next couple of days after picking up a knock," Wenger told Sky Sports.
Jose Mourinho: "He doesn't need to make peace because there are no problems. In the last match at Old Trafford, we shook hands before and after. I remember that I still met him in the corridor for the press conferences, and we shook hands again. When there is peace, we don't have to have a problem. I am a big boy, I'm in football all my life. I know a problem on the pitch, the next day is not a problem at all. So for me not a problem. He (Wenger) will be really pleased with me that I am going to change my team against Arsenal. We have to be human with the players," Mourinho was reported as saying by the Daily Mail.
Betting Odds (betfair)
- Arsenal: 19/20
- Draw: 27/10
- Manchester United: 16/5
Possible XI: Cech; Gabriel, Koscielny, Mustafi; Oxlade-Chamberlin, Ramsey, Coquelin, Monreal; Sanchez, Giroud, Ozil.
Possible XI: De Gea; Darmian; Bailly, Jones, Blind; Carrick, Pogba; Mata, Mkhitaryan, Lingard, Martial.