Bobs Worth ridden by Barry Geraghty claimed the Cheltenham Gold Cup by five lengths as Nicky Henderson claimed his 50th win at the festival.
The pre-race favourite (11-4) began slowly but jumped the last fence in the lead before holding off Sir Des Champs to claim a third successive win at Cheltenham after wins in the Albert Bartlett in 2011 and last year's RSA.
The 2011 winner Long Run led until the final two fences but faded to finish third behind Sir Des Champs.
Victorious jockey Geraghty said: "He's a great attitude, he struggled on the ground but he kept fighting.
"I was hunting and I knew coming into the second last I would win. He's as game as a lion and he loves the job."
Henderson added: "Everyone has done a hell of a job. Bob's Run hasn't run since the Hennessy and Long Run hasn't run until the King George so it's all down to the team at home.
"They've all been absolutely brilliant in putting up with me."
Geraghty claims his second major win of the week having ridden home on Sprinter Sacre in the Queen Mother Champion Chase on Wednesday.