The Senegalese international picked up a hamstring injury in October's international break and was sidelined for a month. He returned to action against in the Merseyside club's league win by West Ham United earlier in November.
Mane played the full 90-minutes in order to help Senegal beat South Africa 2-0 on 10 November. The win helped the Lions of Teranga qualify for the next summer's World Cup in Russia. Following the match, the Senegal Football Association revealed the ex-Saints star will return to Liverpool after the slight recurrence of "his old injury."
There were doubts over the 25-year-old's involvement to face his former club, when Southampton visit Anfield on 18 November. Jurgen Klopp also confirmed the attacker will be assessed for the weekend league clash.
According to the Liverpool Echo, Mane returned to Melwood on Tuesday and completed two days of rehab. He has been declared fit and has been given "green light" to return to full training on Thursday.
Mane will be looking to put the difficult time behind him as he had a start-stop season so far. He was shown a straight red for his kick on Ederson in Liverpool's league defeat to Manchester City.
The forward missed three domestic matches and the hamstring injury in October restricted him to just six league appearances this season. His return to full training will provide an opportunity for Klopp to unleash the quartet of Mane, Roberto Firmino, Mohamed Salah and Philippe Coutinho from the start for the first time this season.
Coutinho has also declared himself fit after he returned to the pitch in Brazil's international friendly against England. He missed Liverpool's last three games with an adductor muscle injury. The 25-year-old played 68 minutes against the Three Lions at Wembley, which has made himself available for Southampton clash.
Salah, who moved to Anfield from AS Roma earlier in the summer, has never started a match alongside the above mentioned players. Injuries to Mane and Coutinho delayed quartet the opportunity to start a game together.