Kevin de Bruyne
De Bruyne will miss his side's second trip of the season to Old Trafford. Getty

Manchester City will be without Kevin de Bruyne for Wednesday's (26 October) EFL Cup fourth round clash with Manchester United, with Pep Guardiola set to make a number of changes to his side.

De Bruyne, 25, was replaced by Kelechi Iheanacho at half-time during Sunday's 1-1 draw with Southampton. Speaking at a press conference ahead of the trip to Old Trafford, Guardiola told reporters the Belgium international is struggling with a minor calf problem, but the injury is not thought to be serious enough to rule him out of Saturday's Premier League clash with West Brom.

The City boss faces a bigger problem at right-back, however, with Pablo Zabaleta failing to recover from a foot problem and Bacary Sagna also still unavailable.

Vincent Kompany, meanwhile, made his first league start of the season on Sunday but Guardiola is wary of starting his captain for the second time in four days.

"Kevin, no way, he cannot play," Guardiola said, via the club's Twitter account. "Pablo I think cannot. Vincent, I think he can, but I don't know today. I need to see training and regeneration [before making a decision]."

City youngsters Angelino, Aleix Garcia and Brahim Diaz all featured in the club's third round victory over Swansea City in September. Wth his side now without a win in their last five games, Guardiola has avoided bringing them back in with his side struggling for form, but has suggested that may change on Wednesday.

"We are going to rotate. Some are going to play. I need to see the players today in training and after we will decide the team. We didn't win in five - young players need to play in a good environment. You have to protect them. We have other options."

City beat United in the first Premier League meeting between Guardiola and Jose Mourinho in September.