Where to watch live
Kick-off is at 12:30pm GMT. Live coverage of the match will be available on Sky Sports 1 and Sky Sports 1 HD. Catch the highlights on Match of the Day on BBC One and BBC One HD at 10:30pm GMT.
United come into this game after registering a comfortable 3-1 victory over Swansea City at the Liberty Stadium before the international break. The victory was their first since defeating champions Leicester City at home in September.
Jose Mourinho was delighted to see his side bounce back against the Welsh club following their disappointing defeat at the hands of Fenerbahce earlier that week. Paul Pogba opened the scoring with a screamer before Zlatan Ibrahimovic extended the lead.
The Swedish striker is suspended for the tie against the Gunners after he received his fifth yellow card of the season at Swansea. Mourinho is likely to start Marcus Rashford, who will lead United's attack against the Gunners.
Arsenal, on the other hand, were forced to settle for a 1-1 draw against Tottenham Hotspur prior to the international break. Harry Kane converted from a spot kick as he cancelled Kevin Wimmer's own goal in helping his side walk away from the Emirates with a point.
Arsene Wenger's side have lost only one game this season, which came on the opening day of the season against Liverpool. However, the Frenchman is yet to register a win against a side managed by Mourinho.
The north London club have injury concerns over the Spanish duo of Santi Cazorla and Hector Bellerin for their trip to Old Trafford. Wenger will have to make a decision on Alexis Sanchez for the clash against United, despite the player declaring himself fit to face the Red Devils.
When Arsenal last visited United earlier this year, it was Rashford who caused trouble to the Gunners. The England international scored a brace before assisting Ander Herrera in his side's 3-2 win.
What managers say
Jose Mourinho: "I thought Michael [Carrick] was the stability, Marouane [Fellaini] was the balance, [Paul] Pogba was the freedom, and all of them together meant the performance (against Swansea) was very positive for us."
Arsene Wenger: "Of course (I will shake hands). I respect the ritual that is so important in the Premier League."Look, I don't think I have to describe our relationship. He will fight for his team and I will fight for my team and I think that's completely normal."
Betting Odds (betfair)
- Manchester United: 6/4
- Draw: 21/10
- Arsenal: 2
Possible XI: De Gea; Darmian, Jones, Rojo, Blind; Herrera, Carrick, Pogba; Mata, Rooney; Rashford
Possible XI: Cech; Jenkinson, Mustafi, Koscielny, Monreal; Coquelin, Xhaka; Walcott, Ozil, Iwobi; Giroud