Where to watch live
Kick-off is at 8pm BST. Live coverage is on BT Sport 1. Radio commentary of the game will be available on BBC Radio 5 Live.
United were forced to settle for a goal-less draw against West Bromwich Albion in their last league outing at Old Trafford. The hosts were without the services of Zlatan Ibrahimovic and Ander Herrera, who were suspended. Paul Pogba was recovering from his hamstring injury.
The Red Devils will be hoping they can bounce back against Everton after failing to find the back of the net against the Baggies. Another draw at home could dent their chances of finishing in the top four, which is one of the routes for United to qualify for the next season's Champions League.
Jose Mourinho will be hoping to see a reaction from his men after a disappointing draw against West Brom. United manager will be looking for nothing less than a win when they host the Merseyside club on Tuesday.
Everton enter this tie after suffering a 3-1 defeat at the hands of Liverpool in the Merseyside derby. Sadio Mane opened the scoring for the Reds in the eighth minute and that was cancelled by Matthew Pennington's 28th minute strike.
However, Philippe Coutinho's individual brilliance three minutes later helped Liverpool to restore the lead before Divock Origi scored the third goal in the second half. The Toffees' trip to Anfield ended in a disappointment and they will be looking to bounce back when they take on United.
Ronald Koeman will be pushing for a victory when they make a trip to Old Trafford. Everton are struggling with injuries and the Dutchman will be hoping the players available at his disposal can fire his side to seal a victory over the Red Devils.
What managers say
Jose Mourinho: "One day yes, one day no. For teams at this level if you want to win things, you need to be consistent. Today for 90 minutes, Antonio Valencia was consistent, Marcos Rojo, Eric Bailly, Ashley Young, Marouane Fellaini, Michael Carrick. The other ones were not consistent. It was a flash of talent, a glimpse. Almost a goal, but we need to kill opponents. Somebody who saw our goals record would think we are a defensive team, a counter-attack team that doesn't have ambition. But it is completely the opposite. Rashford, Lingard, Mkhitaryan, Martial, see how may goals they score. Zlatan and [Juan] Mata are the ones with more goals. If it wasn't for them the situation gets even more difficult," Mourinho was reported as saying by the Daily Mail.
Ronald Koeman: "Rom really thinks a lot about football and he's really honest in his performances, but we had maybe three or four times a counterattack where our final ball was not good. The free-kick from Ross, the back post to Ashley [Williams] – if he hit the ball good then Rom would score and the whole story is different. Also as a striker you need support, you need assists, but I think his work rate and his freshness was not 100%," Koeman told The Guardian.
Betting Odds (betfair)
- Manchester United: 8/13
- Draw: 3
- Everton: 11/2
Possible XI: De Gea; Valencia, Bailly, Rojo, Young; Pogba, Herrera; Mkhitaryan, Pogba, Martial; Ibrahimovic.
Possible XI: Robles; Holgate, Jagielka, Williams, Baines; Barry, Gueye, Davies; Mirallas, Lukaku, Barkley.