mcconaughey & harrelson
Matthew McConaughey and Woody Harrelson teams up anew in the latest American Horror Story thoughtsfired/Instagram

Matthew McConaughey and Woody Harrelson have reunited on screen in a bizarre new comedy that turns their famously close friendship and a real-life rumour that they could be brothers into its central mystery.

The True Detective stars play fictionalised versions of themselves in Brothers, an eight-part Apple TV comedy premiering this week, in which their decades-long friendship is thrown into chaos after a shocking family secret raises the possibility that they share the same father.

The unlikely reunion comes as television prepares for another major return, with American Horror Story: 13 launching its 13th instalment this week. However, McConaughey and Harrelson are not part of the horror anthology's returning cast; their new series is a separate project arriving just one day earlier.

Inside the 'Brothers' Reunion

The pair's latest collaboration comes more than a decade after they became one of television's most memorable duos in the first season of True Detective, with McConaughey playing troubled detective Rust Cohle and Harrelson portraying his partner Marty Hart.

This time, their relationship is being mined for comedy as the actors exaggerate elements of their real friendship and turn an unusual family rumour into an increasingly chaotic television plot.

In Brothers, Woody's daughter's engagement falls apart, prompting him to take his family to Matthew's Austin ranch for an extended stay. What begins as an attempt to recover from the family crisis soon takes an extraordinary turn.

The Family Secret at the Heart of 'Brothers'

Matthew's mother, Ma Mac, played by Holland Taylor, accidentally reveals a long-buried secret suggesting that the two lifelong friends might actually be brothers. Woody becomes focused on discovering whether the claim is true, turning Matthew's ranch upside down as he searches for answers.

Matthew, meanwhile, is dealing with his own situation as he considers a potential run for Governor of Texas. The premise deliberately blurs the boundary between fact and fiction, drawing on the pair's real-life friendship while placing fictional versions of the actors inside a heightened family mystery.

From True Detective to Comedy

The reunion marks a clear change of tone from True Detective. Rather than returning as troubled investigators, McConaughey and Harrelson are executive producers and stars of a comedy about friendship, family, fame and the stories that can grow around Hollywood celebrities.

The series also stars Natalie Martinez, Brittany Ishibashi, Nolan Almeida, Ella Grace Helton, Noah Carganilla, Highdee Kuan, Oona Yaffe and Taylor. The show is created and executive produced by Lee Eisenberg, with McConaughey and Harrelson also serving as executive producers.

Arriving Alongside American Horror Story

The timing gives the reunion an additional television hook, with American Horror Story: 13 also returning this week. Ryan Murphy and Brad Falchuk's horror anthology is bringing back an ensemble of familiar stars, including Sarah Paulson, Evan Peters, Angela Bassett, Kathy Bates, Emma Roberts and Jessica Lange.

The 13th instalment is set to feature 13 half-hour episodes and revisit characters including Constance Langdon, Cordelia Goode and Madison Montgomery.

While McConaughey and Harrelson are not joining American Horror Story, their reunion arrives at almost exactly the same moment, giving viewers two different high-profile television returns to watch.

Brothers premieres globally on Apple TV on September 23, with its first two episodes followed by a new episode each Wednesday through November 4. Fans of the McConaughey and Harrelson on-screen partnership can also revisit their American Horror Story performances.