Roberto Mancini
Manchester City's manager Mancini shields his eyes during a news conference at the club's Carrington training complex in Manchester. REUTERS

Manchester City make their Champions League debut at home to Napoli Wednesday, as they look to test their domestic form against Europe's elite.

Roberto Mancini's side find themselves in arguably the toughest group in this year's draw, with Bayern Munich and Villarreal rounding out Group A.

City last appeared at this level in 1968 when Fenerbache knocked them out in the first round. But Mancini remains confident ahead of Napoli's visit following their 100 per cent start to the Premier League season.

"I think this is normal for us. Now Manchester City are one of the best teams in England and Europe," he told BBC Sport.

"For us, it will be very important to do our job very well in this group. The first game is always a difficult game.

"Several of their players have been capped for their national teams and [Walter] Mazzarri is a very experienced manager. I expect Napoli to be a challenge but a lot of our players have played in the Champions League and I don't think they will feel pressure for this game."

Napoli are also making their first appearance in the tournament for 21 years, after Walter Mazzarri's side finished third in Serie A last season.

Marco Donadel missed Saturday's home victory over Cesena but is likely to recover in time for tonight's game, with Mazzarri likely to start Ezequiel Lavezzi and Edinson Cavani.

Manchester City duo Gareth Barry (ankle) and James Milner (concussion) are both doubtful, while Nigel de Jong (foot) remains side-lined.

Edin Dzeko is expected to start after being rested against Wigan at the weekend, with the Bosnian forward expected to partner Sergio Aguero up front.

Predicted: Man City 2-0 Napoli

Man City possible XI: Hart; Richards, Kompany, Lescott, Clichy; Nasri, Y Toure; Johnson, Silva, Aguero; Dzeko.