Owen Farrell and Ben Youngs, the halfbacks potentially key to England's assault on the 2015 World Cup, will get a taste of operating under the highest pressure in the Six Nations decider against Wales.
Flyhalf, Farrell, missed last week's 18-11 victory over Italy with a thigh strain but comes back in for Toby Flood, while 23-year-old Youngs will start in Cardiff having edged out Danny Care in the team named by coach Stuart Lancaster on Thursday.
Tom Croft, who appeared as a replacement against Italy 11 months after breaking his neck, starts at blindside flanker instead of James Haskell while Joe Marler is back at prop for Mako Vunipola in the two other changes from last weekend.
Victory for England on Saturday would give them their first grand slam since 2003 but they could lose and still win their second championship in three years if the defeat is by less than eight points.
Defending champions Wales, who will name their team later on Thursday, would also take the title with a seven-point win as long as England do not score three more tries than them in Saturday's match.
Presented by Adam Justice