- Joel Matip unavailable due to player's eligibility row with Cameroon.
- Nathaniel Clyne ruled out with rib injury - 18-year-old Trent Alexander-Arnold comes into replace him at right-back.
- Jordan Henderson fit to start and captain his side but Philippe Coutinho starts on the bench alongside Daniel Sturridge.
- Zlatan Ibrahimovic and Marcos Rojo both return to the starting XI after missing EFL Cup win over Hull City due to illness and injury.
- Liverpool start the day in fourth place with Manchester United sixth.
- Jose Mourinho's side can move to within two points of their arch-rivals if they win at Old Trafford this afternoon.
Full-time: Manchester United 1-1 Liverpool
What a chance for Wijnaldum to win it! Again on the counter, Lallana turns inside the box to find the overlapping Dutchman free, but his meek effort is sent straight at De Gea.
Herrera cynically hauls back Firmino to halt a counter attack and the Liverpool man responds by shoving the Spaniard to the ground. Both men get a yellow for their trouble. Four minutes of time added on.
The Old Trafford crowd howls for hand ball as Rooney flicks the ball at Alexander-Arnold but it clearly comes off the chest of the Liverpool defender.
United are level! Valencia looks half a yard offside as he swings in a cross from the right, finding Rooney who clips a ball into Fellaini. His header is just off target, bouncing off the outside of the post but Ibrahimovic is following it up, hacking it over line to level the contest. Five minutes remain.
Goal! Manchester United 1-1 Liverpool (Zlatan Ibrahimovic, 83)
Rooney denied his record! He lashes a knockdown from Mata on goal but Mignolet makes an important stop with his legs. The offside flag is up, but the United skipper was clearly onside.
Marcus Rashford won't get a chance to come on and rescue his side today, Marouane Fellaini comes on for Darmian.
Liverpool almost get a second and it is Pogba at fault again. He tries to backheel to a teammate on the half-way line but it is easily intercepted and the counter attack comes, with Wijnaldum heading over at the end of it.
18 minutes left for United to rescue something here.
Klavane is down at the moment getting some treatment after a nasty challenge from Rooney. Duelling for a 50-50 ball, the United skipper appeared to tread on the Liverpool defender's right foot.
Rojo sees his clearance inside the box bounce off one of his teammates into Lallana who turns and fires, but his effort is stopped by De Gea.
Here's United's second change of the match, Juan Mata enters the fray to replace Martial.
United continue to turn the screw. Mkhitaryan slides a cleverly disguised ball into Rooney but he drags his shot woefully wide.
Straight away, Coutinho is involved, driving at the United defence down the inside left channel before flicking a ball through for the onrushing Frimino. He shoots for goal, but de Gea is out to make an important block.
Here's Liverpool's first change of the game, Philippe Coutinho comes on for Origi.
Liverpool are pinned back at then moment but United are still struggling to find that telling ball to pick through.
Valencia now threads a ball down the right for Rooney, who turns and fires across goal but it is an easy collect for Mignolet.
Martial does well to win the ball from Alexander Arnold and force the ball onto Ibrahimovic. He slides a ball through for Mkhitaryan who has come racing down the inside right channel but his cross back across the face of goal has too much on it and Martial cannot get on the end of it.
Having been taken off marking Lovren, Pogba meet the corner to head it away before Herrera wins a free kick for his side. Up the other end, Rooney earns a free kick for his side.
Liverpool have started this half sharper on the counter with Origi seeing his curling effort from the left deflected just wide.
United are making a change at half-time; Wayne Rooney on to replace Michael Carrick.
Half-time: Manchester United 0-1 Liverpool
The Reds lead through James Milner's penalty. Manchester United, and more specifically, Paul Pogba, have been wretched.
For the fifth time today, Lovren easily loses Pogba as Liverpool lift a set piece into the box. It's quite unbelievable that Jose Mourinho hasn't got someone else marking the Liverpool defender.