Where to watch live
Kick-off is at 2.15pm GMT. Live coverage of the match will be available on Sky Sports 1 and Sky Sports 1 HD. Radio commentary of the game will be available on BBC Radio 5 Live. Catch the highlights on Match Of The Day 2 on BBC One at 10.30pm GMT.
United and Tottenham enter this fixture after qualifying for the Europa League Round of 32 following their victories in the final group stage fixture of the European competition. The Red Devils progressed following their 2-0 win over Zorya Luhansk in Ukraine.
Summer signing Henrikh Mkhitaryan scored his first goal against Zorya before Zlatan Ibrahimovic doubled the lead, courtesy of Paul Pogba's assist. The duo, along with the world-record signing are expected to start against the north London club.
Goalkeeper David de Gea, defender Antonio Valencia and midfielder Michael Carrick did not travel to Ukraine. The trio could return to the starting lineup to face Tottenham. Jose Mourinho has seen his side struggle in the league as they have not won a game since their 3-1 win over Swansea City.
In the last eight league games played, the Portuguese tactician has seen United settle for a draw on six occasions. This included a 4-0 defeat at the hands of Chelsea and the victory over Swansea City.
Tottenham made it to the Europa League following their exit from the Champions League as they finished third in their group following their victory over CSKA Moscow. Mauricio Pochettino has also seen his side settle for draws in the recent past, which was overcome by two wins in last three fixtures.
A victory for the visitors at Old Trafford will be a massive boost in their bid to chase for a place in the top four. They have managed nine goals in last three games and will be looking to extend that record when they face United on Sunday.
What managers say
Jose Mourinho: "I find it unfair, I find that we should have much more points than we have because you look at the table and it looks like other teams are better than us which, in my opinion, is not true. So many draws that we deserve victories. If you could transform these draws into victories we would be very close to the top of the league, in between the top three or top four so I find more unfair but there is only one way - keep working," Mourinho was reported as saying by the Daily Mail.
Mauricio Pochettino: "Jose is always direct and honest. He tells you the truth. I met him when I was at Espanyol and he was kind to me – not just because he gave me a bottle of wine but he told me some truths about what a young manager like me could expect. His behaviour is no different to a lot of other managers but because he is The Special One, people, the referee and the media focus on him. But if you compare him with other managers, they can behave worse than him but they don't attract attention because they are not special like him," Pochettino said, as reported by The Sun.
Betting odds (betfair)
- Manchester United: 6/5
- Draw: 12/5
- Tottenham Hotspur: 27/10
Possible XI: De Gea; Valencia, Bailly, Rojo, Darmian; Herrera, Pogba, Carrick; Martial, Rooney, Mkhitaryan; Ibrahimovic.
Possible XI: Lloris; Walker, Dier, Vertonghen, Rose; Wanyama, Dembele; Eriksen, Alli, Son; Kane.