Hugo Lloris, Jan Vertonghen and Kyle Walker are all doubts for Tottenham Hotspur's visit to Newcastle United on Sunday 19 April.
Lloris, 28, has missed the clubs last two games as a result of a knee tendon injury he suffered in the 4-3 win over Leicester City in March.
Vertonghen also missed the games against Burnley and Aston Villa due to illness, while Walker is still struggling with a foot injury he suffered at Turf Moor following a collision with Kieran Trippier.
Tottenham boss Mauricio Pochettino stopped short of ruling the trio out of the trip to St James' Park but plans to assess their fitness after a final training session on Saturday.
"All three are doubts," Pochettino told a pre-match press conference on Friday. "We have another training session tomorrow and we will then assess their levels, see how they are and make a decision."
Tottenham will travel to the north east with hopes of closing the gap on the Premier League's top four, but Sunday's match could be overshadowed by a planned boycott of the match by sections of Newcastle's support.
Pochettino is sympathetic towards his opposite number John Carver, the man caught in the middle of the unrest at Newcastle, but is unsure what effects the planned protest could have on the opposition.
"We don't know (what will happen). Sometimes the effect on the players is positive. Sometimes the players are scared and run more," the Tottenham boss said. "Or sometimes they feel under pressure and don't show their faces. You never know and it is difficult to guess what will happen on Sunday.
"I always think you care about another manager because you can be in the same position, too. In your career sometimes you are up and sometimes you are down. You suffer a lot when things are not good. So for that reason I care a lot about him."