Zlatan Ibrahimovic, Paul Pogba and Marcos Rojo are all in contention to face Newcastle United after Manchester United boss Jose Mourinho confirmed the trio have fully recovered from their respective injuries.
Neither Ibrahimovic or Rojo have not played for seven months after undergoing surgery on knee ligament injuries suffered in the Europa League against Anderlecht in April.
Pogba meanwhile has been ruled out since September with a hamstring injury picked up against FC Basel and has missed 13 games as a result, but is back in the fold after ramping up his recovery during the international break.
"The players that stayed here recovering from injuries, even the ones that are recovering from big injuries, they are ready to play," Mourinho told MUTV.
Despite scoring 28 goals last season in his maiden campaign in England, Ibrahimovic was released by United at the end of last season as he begun his rehabilitation, with his return date pencilled in for the start of 2018.
The former Sweden captain stunned United's medical officials by the rate of his recovery and in August re-joined the Old Trafford club until the end of the season.
Mourinho can now call upon the 36-year-old, starting against Newcastle, however the Portuguese coach has warned Ibrahimovic will be unable to play a full 90 minutes or back-to-back games this term.
"Zlatan last season we played with him every minute almost until he was injured, this season we learn how to play without him but he's a very important player for us and of course welcome back, of course incredible personality to fight such an important injury, we were all saying in 2017 he will be back but one thing is 31 Dec 2017 and another thing is mid-November," he told the media, according to the Manchester Evening News.
"He made a full recovery, now you cannot expect him to play 90 mins or consecutive matches like he did all his career, now he needs time to be back for his level, his fitness, his confidence, everything, his sharpness, but by the clinical point of view it is fantastic to be ready."
Argentina defender Rojo was also not expected to return before the New Year but has also made a remarkable recovery.
"He was as an injured player the same super pro he is when he's fit," added Mourinho. "So fantastic work, same as Marcos, is an important injury too, a big surgery, he played with the young boys on Wednesday and is fine, is confident, is also ready."
Following over two months out, a wafer-thin United midfield will be boosted by the return of Pogba following initial suggestions he could miss up to three months with a hamstring injury. Mourinho fuelled speculation his absence could be lengthy with a series of indeterminate updates on the Frenchman's fitness but hopes his return will turn around United's recent form.
"Paul, now I can speak because he's back, I don't like to speak while he was injured, but you can clearly see Manchester United this season before Paul's injury and after Paul's injury," he added. "There are qualities in our football, there are qualities that influence our approach in matches with Pogba and without Pogba - it's as simple as that."
Ibrahimovic will now challenge Romelu Lukaku for a starting berth after the Belgium international was entrusted to lead the United attack during the opening months of the campaign.
The 24-year-old has responded with 11 goals in 17 appearances since his summer move from Everton though he has gone seven games without a goal. Former Barcelona and Juventus forward Ibrahimovic has spoken of his desire to play alongside Lukaku, an idea Mourinho is open to.
"It is easy," he explained. "Good players, they can play together. The problem is when the players are not good but, (with) good players it is easy to play together."
Defender Phil Jones, who aggravated a thigh injury while on international duty with England, is out while Michael Carrick remains unavailable due to a mystery illness.