Arsenal will look to secure their first home win of the season when the Saints come marching in to the Emirates. The Gunners play host to the bottom-placed side in the Premier League and new signing blues aside, anything other than three points for Arsene Wenger's side will be a surprise.
Where to Watch Live
Kick-off is set for 3pm BST and live coverage is available on Arsenal Player (for Arsenal.com members). Free and live text updates are available via Gamecast on Soccernet.
Wenger's first concern will be to ensure the good form shown in the Gunners' 2-0 win over Liverpool before the international break continues. New signings Lukas Podolski and Santi Cazorla were both on target at Anfield and will want to impress home fans. Fellow new signing Olivier Giroud continues to struggle to settle in at his new club, but his movement has been good and he is likely to continue in the first team, for now. The Gunners remain the only side in the league yet to concede a goal and that will be good news for Wenger, who has often been criticised for his side's leaky defence.
The other concern Wenger will have is that his side have sometimes been found wanting against lower ranked teams. Arsenal's first games of the season were against a Sunderland and Stoke side who tend to play a rather physical game and those ended in scoreless draws (a result the Saints would probably be happy with). However, the last time they were at home Arsenal had 23 shots on goal... so if Giroud can put one away or Podolski continue his form from Anfield, this should be an easy win.
Meanwhile, newly promoted Southampton need points, and with only four goals to their name they seem unlikely to trouble Arsenal. However, the Saints were unlucky in each of their last two games - against the Manchester clubs no less - forcing their opponents to come back from 2-1 down on each occasion to win 3-2. Manager Nigel Adkins will hope for a better defensive performance, while relying on striker Rickie Lambert to continue finding the back of the net.
Arsenal still have considerable injury concerns, the latest being French midfielder Abou Diaby, whose brief return from an earlier long-term injury was cut short while on international duty with France. In addition, Theo Walcott will take a late fitness test as he recovers from an illness that kept him out of England's World Cup qualifier against Ukraine. Also unavailable are a list of long-term absentees that includes Tomas Rosicky, Bacary Sagna and Jack Wilshere. The good news is that goalkeeper Wojciech Szczesny is available again. Former Southampton player Alex Oxlade-Chamberlain is likely to retain his place in the first team, despite a less than impressive performance for England in mid-week.
Arsenal (4-3-3): Szczesny; Jenkinson, Vermaelen, Koscielny, Gibbs; Coquelin, Arteta, Cazorla; Oxlade-Chamberlain, Giroud, Podolski
Southampton have been boosted by the availability of new signing Gaston Ramirez who was caught up with details regarding international clearance. However, the Uruguay international is likely to remain on the bench owing to lack of match fitness; he has not been involved in any of Southampton's matches this season. Rickie Lambert will remain a key figure up front as the focal point of the Saints' attack. Forward Adam Lallana, who was called up to the England squad for the first time, is touted to be the next big star to make his way through from the Saints' academy.
Southampton (4-4-2): K Davis; Clyne, Hooiveld, Fonte, Fox; Schneiderlin, S. Davis, Ward-Prowse Puncheon; Lambert, Lallana