Surman suffered a knee injury in the first-half of Saturday's goalless south coast derby against Southampton. The former Saints youngster carried on until half-time but the knock eventually forced him off early in the second-half.
Howe revealed post-match the midfielder had twisted his knee while attempting to put his side at St Mary's and ahead of his side's trip to Anfield, the Cherries boss admitted a return before the end of the campaign now looks unlikely.
"Andrew Surman will definitely be out and that's a blow for us. It's hard to say right now, but that could be his season," Howe told a press conference on Tuesday.
"The emotions from the weekend were varied. We felt we should have won, but we weren't at our best in the first half."
Howe added he has a number of other fitness concerns to contend with but refused to reveal who they concern ahead of kick off. The Cherries are seven points clear of the relegation zone with eight games of the season remaining but face a gruelling run of fixtures in April. After their trip to Liverpool, they welcome league leaders Chelsea to Dean Court before travelling to north London to take on Tottenham Hotspur.
"We'll try and make the right team selection based on who we have available," said Howe of his upcoming selection decisions. "We may make changes to try and get the balance between tired bodies and keen players, but we'll see."