Moors Murderer Ian Brady died at a high security psychiatric hospital 51 years after being convicted of torturing and murdering five children.
One of the nation's most infamous serial killers, Brady was confirmed to have died by the Mersey Care NHS Foundation Trust.
The 79-year-old was convicted along with his partner Myra Hindley in 1966, who died in prison in 2002 aged 60.
To this day, one of the five bodies remains missing, the location never revealed by the pair, despite opportunities to visit the Moors where the other bodies had been hidden.
Pauline Reade – 16
Pauline was Brady's first victim, when she disappeared on 12 July 1963, while she was on her way to a disco near her home in Gorton, Manchester.
It took another two decades before her parents found out what happened to her, when her body was found in 1987 after the murderers confessed and led detectives to her gravesite.
She was found on Saddleworth Moor, still wearing her pink and gold party dress and blue coat.
Her relatives later said her mother, Joan, who died in 2000, never got over the pain of losing her and suffered ill health for years.
John Kilbride – 12
Just four months after Pauline Reade disappeared, John became the second victim.
He was lured on to the moor, where he was sexually assaulted and murdered.
"My mother always used to be singing when she was cooking or ironing but that just stopped. Everything died," his brother Terry told the Daily Telegraph years later.
Keith Bennett – 12
Despite a campaign that lasted almost 50 years, Winnie Johnson died in 2012 never knowing what Brady did with the body of her son, Keith, in 1964.
He became the murderers' third victim when he was abducted after leaving his home in Chorlton-on-Medlock, in Manchester on 16 June that year.
Police mounted an intensive search of the moor in 1986 amid reports that the pair had confessed to his murder. But even though Brady and Hindley were both permitted to travel to the moor to try to remember where the boy's remains were, his body was not found.
"Winnie fought tirelessly for decades to find Keith and give him a Christian burial," read a family statement on her death. "Although this was not possible during her lifetime, we, her family, intend to continue this fight now for her and for Keith. We hope that the authorities and the public will support us in this."
Lesley Ann Downey – 10
The youngest victim died on Boxing Day in 1964, after being lured away from a fairground to the house which Hindley shared with her grandmother in Hattersley, Greater Manchester.
Brady sexually abused and tortured her, forcing her to pose for sexually explicit photographs. The murderers even recorded an audio tape of her brutal final moments that reduced a court room to tears when it was played back.
Her step-father, Alan West, died last year without his wish to see Brady go first being granted. "While he's alive, it's still haunting me. I know it will never leave my mind about our Les. But, perhaps it may help," he told the Manchester Evening News, in 2012, in one of his final interviews.
Edward Evans – 17
Edward was the final victim. The apprentice engineer was lured to a home then shared by Hindley and Brady.
The pair summoned Hindley's brother-in-law, David Smith, to the house on a false pretext and forced him to watch as Brady murdered Edward. Edward was described as "tall and slim, with light-brown hair and an engaging smile". It has been reported that Edward has no living relatives.
It was this moment that lead to the whole case unravelling.
Smith helped the pair carry Edward's body into a bedroom. In terror, he fled and called the police.
The next morning, officers searched the house and began unravelling the gruesome evidence of Brady and Hindley's appalling crimes.