Chelsea duo Frank Lampard and Ryan Bertrand are the latest players to be ruled out of England's World Cup qualifier in Poland.
Both players missed the victory over San Marino through injury and illness respectively, with recurring issues keeping them out of the trip to Warsaw.
The Blues pair join Theo Walcott on the side-lines for the mid-week game after his chest injury picked up during his collision with San Marino goalkeeper Aldo Simoncini, keeps him out.
The triple loss hands Hodgson a selection headache ahead of a potentially tricky tie against the Euro 2012 co-hosts.
Hodgson will welcome back captain Steven Gerrard to the side after his suspension against San Marino, while experienced faces such as Ashley Cole and Glen Johnson are also set to return.
Lampard remains out of action with a calf problem, while leaves him a major doubt for Chelsea's trip to Tottenham Hotspur, while illness to Bertrand persists.
The Chelsea full back took to Twitter last week to rubbish claims a sore throat would keep him out of the game, however quickly removed the message after including a swear word in the post.
Bertrand has subsequently deleted the account, a move which comes a week after The Football Association unveiled a list of guidelines which all England players are ask to adhere to. Any breach of the rules could lead to an international suspension.
Another Chelsea player, in full-back Cole, ran into trouble on Twitter a fortnight ago when he labelled the FA a 'bunch of t**ts'.
Cole was charged with misconduct by The FA, but was not suspended for the World Cup qualifier against San Marino, instead being left out at the expense of Leighton Baines.
The Everton defender played a part in two of England's goals in their 5-0 win over the side ranked 207th in the world, and teammate Phil Jagielka believes the 27 year old is close to eclipsing Cole as the country's in form left-back.
"I don't see there's any difference really," Jagielka said. "Ashley has performed at that level for a long time now and put himself up there as one of the world's top left-backs.
"But if you watch Bainesy enough, and he won't thank me for saying it, he's been by far our best player all season."