Hector Bellerin and Santi Cazorla both look set to miss Arsenal's trip to Manchester United on Saturday (19 November), with Arsene Wenger confirming the right-back will be out for around four weeks with an ankle injury. The Gunners boss also added that Alexis Sanchez will need to be assessed prior to the Old Trafford clash after the Chile international suffered a hamstring scare while on international duty.

Bellerin joined up with the Spain U21 squad over the international break with hopes of shaking off the issue sustained during the derby with Tottenham Hotspur.

However, the former Barcelona academy starlet was forced to withdraw from U21 duty after he was unable to train with his teammates.

IBTimes UK revealed at the time that subsequent medical tests confirmed Bellerin had damaged the ligaments of his ankle, ruling him out of action for between three and four weeks. This period includes the Gunners visiting Manchester United as well as the Champions League clash with Paris Saint-Germain.

Wenger has now confirmed the news in a press conference ahead of the game with United.

"Hector is out for four weeks" Wenger said. "He got injured in the last 10 seconds against Spurs in a very strong tackle from Danny Rose. "

Earlier this week, Cazorla revealed he was going to miss the trip to Manchester United as he is still trying to recover from the Achilles' tendon injury sustained during the 6-0 victory over Ludogorets on 19 October. Wenger has now added that the Spanish playmaker is yet to train with the rest of his Arsenal teammates, suggesting he could also miss the Champions League crucial clash with PSG on Wednesday night.

"Cazorla is still out. For how long exactly I don't know. He's not even out training," Wenger added.

Alexis Sanchez's availability to face United has also been subject to doubt in recent days after he suffered a hamstring injury on international duty with Chile. The 27-year-old forward missed his country's World Cup qualifier against Colombia but returned in sensational form for their match against Uruguay on Tuesday, scoring two goals.

The former Barcelona star declared himself fit after the game but Wenger revealed club doctors will have the final word, as they don't want to take any risks with the player. Prior to Chile's encounter with Colombia, Wenger had warned Juan Antonio Pizzi against playing Sanchez, fearing the minor injury could be amped up.

Wenger has now added: "We didn't know whether or not he would play 24 hours before the Uruguay game. In the end they decided to play him. He texted us saying he was in good shape after the game but we have to wait. I will see him tomorrow morning and see if he can be involved in the squad or not. What I will consider is basically the risk of injury."

The visit to Old Trafford will also come too early for Lucas Perez as the forward continues his recovery from the ligament ankle injury sustained during the EFL Cup fourth-round victory over Reading on 25 October.