Celebrated game designer Hideo Kojima has unveiled a brand new trailer for Kojima Productions' mysterious debut game Death Stranding at The Game Awards 2016.

The latest look at the upcoming game features one of Kojima's favourite actors, Hannibal star Mads Mikkelsen, and director Guillermo del Toro as another character. The creepy video shows del Toro's character carrying a baby in an incubation chamber while trying to hide from soldiers and tanks in a dystopian, war-torn city.

A baby doll seen floating down a stream of water into a dark sewer tunnel, finds its way to a group of armed soldiers, who emerge with black oil-like liquid seeping from their eyes.

The leader of the military unit then removes his helmet, revealing his face to be that of Danish actor Mads Mikkelsen.

The trailer (embedded below) ends with the broken baby doll floating before Mikkelsen smiles at the camera with one bright blue eye open.

Mikkelsen and del Toro join The Walking Dead star Norman Reedus, who will play the player-controlled protagonist.

The Game Awards host Geoff Keighley noted that the footage was running in real-time on a PlayStation 4 Pro. Following the trailer's premiere, Kojima tweeted two new posters for the upcoming game.

Kojima accepted this year's Industry Icon Award at the awards after his ex-employer Konami barred the Metal Gear Solid creator from attending the show last year. Describing Kojima as a great and honourable man, an emotional Keighley said: "We had to be back on stage this year, to give one man a moment he was robbed of."

Announced at Sony's E3 2016 press conference with another strange, cryptic trailer, Death Stranding will be launched as a console exclusive for PS4 and on PC.

Kojima has yet to announce a release date for the intriguing new game but teased earlier this year that it "will be out before the year in which Akira is set". The 1988 anime film is set in 2019.