Gareth Bale, Sergio Ramos and Fabio Coentrao have been left out of Real Madrid's squad for the Champions League game against Liverpool on Wednesday 22 October, the Spanish club confirmed.
However, Carlo Ancelotti has included both Raphael Varane and Karim Benzema after the pair missed the La Liga victory over Levante on Saturday 18 October.
The Champions League holders visit Anfield as the leaders of the group after beating both Ludogorets and Basel in the first two games – while Brendan Rodgers' side beat the Romanian team but lost to the Swiss side.
On Monday 20 October Real Madrid revealed Bale was likely to miss the game after suffering a gluteal injury.
The former Tottenham star had been left on the bench during Real's La Liga win over Levante and is reportedly expected to be on the sidelines for up to 10 days, meaning he will probably miss the Clasico against Barcelona on Saturday 25 October.
Meanwhile, Ramos has not travelled to Liverpool despite recent reports in Spain claiming he was ready to return to action after two weeks on the sidelines.
But with the Clasico on the horizon, Ancelotti opted to leave him out of the squad in a bid to have him fully fit for the crucial game against Barcelona.
Also, as expected, Coentrao misses the game after he suffered a knee injury against Atletico Madrid on 13 September. The Portugal international has been out of action since that match.
Ancelotti is expected to deploy Raphael Varane, Isco and Marcelo to replace the injured players, while youngster Nacho could also start in defence.
The predicted line up will see Iker Casillas in goal, with Dani Carvajal, Pepe, Varane and Marcelo in defence. Toni Kroos, Luka Modric, Isco and James Rodriguez will form the midfield while Cristiano Ronaldo and Benzema are expected to lead the attack.
Here it is the full squad named by Ancelotti for the game against Liverpool:
Goalkeepers: Iker Casillas, Keylor Navas and Pacheco.
Defenders: Raphael Varane, Pepe, Marcelo, Dani Carvajal, Alvaro Arbeloa and Nacho.
Midfielders: Sami Khedira, Toni Kroos, James Rodriguez, Luca Modric, Isco, Illarra, Alvaro Medrán and Marcos Llorente.
Strikers: Cristiano Ronaldo, Karim Benzema and Javier Hernandez.