Where to watch live
Kick-off is at 8pm BST. Live coverage of the match is on Sky Sports 1 and Sky Sports 1 HD. Radio commentary of the game is available on BBC Radio 5 Live.
Jose Mourinho is a disappointed man at the moment as he saw his United side suffer a crushing 4-0 defeat at the hands of Chelsea in the last league tie on 23 October. It was for the first time the Portuguese tactician returned to Stamford Bridge since facing the sack last December.
Things did not go as per the plan as a defensive error resulted in a goal in the first minute of the match. Pedro made no mistake to give the hosts an early lead. A goal before the break followed by two goals in the second half was humiliating for the Red Devils to suffer a defeat.
In the previous round, a comfortable 3-1 win over Northampton Town saw United progress further in the tournament. Mourinho will be hoping his side can end their disappointing run in the derby on Wednesday evening.
City, on the other hand have also not been enjoying a great run of results as they are without a win in the last five matches played in all competitions, which includes two defeats. The first defeat came in the league at the hands of Tottenham Hotspur, followed by a 4-0 loss to Barcelona in the Champions League.
In the last league tie, Pep Guardiola saw his side come from behind to settle for a 1-1 draw against Southampton. Kelechi Iheanacho's second half goal cancelled Nathan Redmond's 27th minute goal.
United faced City in the league earlier in the season and Mourinho saw his men suffer a 2-1 defeat. The former Real Madrid and Chelsea manager will be hoping the result is different when these two sides face each other in the EFL Cup clash at Old Trafford.
What managers say
Jose Mourinho: "I would prefer to play [next] in the EFL Cup. It's a bad feeling in the EFL Cup. With the combination of results, the gap to the top is six points. We have had a very difficult period of matches. We lost points this week and, even in the match when we played phenomenal against Stoke [a 1-1 draw], we lost points then. Now we need to win matches."
Pep Guardiola: "Our last few games have been tough. If you are winning a game 3-0 in the last 15 or 20 minutes you can have more control and it gets a little easier. But we were playing 10 against 11 against Barcelona, it's physical and tough in the Champions League. After that there was the game against Southampton, when we made a mistake to go behind."
Betting Odds (betfair)
- Manchester United: 29/20
- Draw: 23/10
- Manchester City: 15/8
Possible XI: Romero; Darmian, Smalling, Fosu-Mensah, Shaw; Carrick, Pogba; Rashford, Rooney, Martial; Ibrahimovic
Possible XI: Bravo; Stones, Otamendi, Kolarov; Sane, Fernandinho, Gundogan, Sterling; Navas, Silva; Aguero