The winger-turned right-back has featured in six matches in April, including the 120 minutes against Anderlecht in the second leg of the Europa League quarter-final tie at Old Trafford. He missed the league clashes against Burnley, Everton and Sunderland. The defender missed the latter two fixtures after citing fatigue as the reason.
Valencia started in United's 1-0 victory over Celta Vigo in the semi-final of the Europa League. The return leg will be played at Old Trafford on 11 May. The clash against the La Liga outfit is sandwiched between the league games against Arsenal and Tottenham Hotspur.
According to the Manchester Evening News, the former Wigan Athletic man has not travelled with the squad to London. It is believed that fatigue is once again cited as the reason as Jose Mourinho wants to keep one of the standout players of this season fresh for the Europa League clash.
The United manager has already admitted that he will rest his key players as his side are focusing on the Europa League. He has included teenage centre-back Matthew Olosunde, 20-year-old Demetri Mitchell and the midfield duo of Matty Willock and Scott McTominay in the squad.
The latter two were on the bench during the league draws against West Bromwich Albion and Swansea City. Eric Bailly, Marcus Rashford and Jesse Lingard have featured regularly in April and the MEN report claims the trio are unlikely to feature against Arsene Wenger's side.
Marouane Fellaini, who started against Celta will not be eligible to face the north London club due to suspension. The Belgium international started alongside Ander Herrera and Paul Pogba, with Michael Carrick and Juan Mata finishing the Europa fixture as an unused substitute.
The Spain international and the former Tottenham midfielder are likely to start against Arsenal on Sunday. With Chris Smalling coming on as a later substitute against the Spanish club and Phil Jones recovering from his injury, the duo could feature in the heart of the back-four.
Meanwhile, Mourinho has already revealed that goalkeeper David de Gea will start against Arsenal. The goalkeeper settled for a place on the bench as Sergio Romero was included in the starting lineup against Celta.