Real Madrid visit the Vicente Calderon to take on Atletico Madrid, in what could be one of the less exciting editions of the Madrid derby due to the Meringues' Champions League commitments.
Where to Watch Live
Kick-off is set for 7pm BST, with Sky Sports 4, Sky Sports 4 HD and Sky Go providing live coverage in the UK.
Madrid know that defeat to their rivals could dethrone them, handing the La Liga title to runaway leaders Barcelona, who play Athletic Bilbao earlier in the day. Also, there is more than just bragging rights at stake in the Spanish capital, as a win for Atletico would move them level on points with their second-placed opponents.
However, Jose Mourinho does not have much of a choice: he has to rest most of his regular starters, with an eye on Tuesday's Champions League semi final second leg against Borussia Dortmund. The Spanish giants are hoping to overturn the 4-1 defeat in Germany.
Atletico are on a five-match unbeaten run in La Liga, winning three of those. Meanwhile, Madrid have won just one of their last four away games in all competitions. However, history favours Los Blancos in this tie as they have won the last nine Madrid derbies. Mourinho's men came out on top in the reverse fixture at the Bernabeu in December winning 2-0, with Cristiano Ronaldo and Mesut Ozil on target.
- Last Five Games (all competitions, most recent first): W W D D W
- Last Match: Sevilla 0 - 1 Atletico Madrid
- Last Five Games (all competitions, most recent first): L W W L W
- Last Match: Borussia Dortmund 4 - 1 Real Madrid
Atletico Madrid: Vice-captain Tiago (muscle tear) has returned to training after a lengthy spell on the treatment table and could start from the bench but fellow midfielder Arda Turan (ankle) is a doubt. Striker Diego Costa had his yellow card against Sevilla overturned on appeal and is eligible to play.
Probable Line-up: (4-4-1-1) Courtois; Juanfran, Miranda, Godin, Filipe; Raul Garcia, Gabi, Suarez, Koke; Diego Costa; Falcao
Real Madrid: Ronaldo, who picked up a thigh strain against Dortmund, has not been included in the travelling squad. Wing-backs Alvaro Arbeloa (back) and Marcelo (muscle tear) remain sidelined but Michael Essien (hamstring) is back in contention. Xabi Alonso is also available after missing the last league outing against Real Betis through suspension. Mourinho is expected to rest the majority of Madrid's key players for this game, as the Special One attempts an improbable comeback against Dortmund.
Probable Line-up: (4-2-3-1) Lopez; Nacho, Albiol, Carvalho, Coentrao; Casemiro, Modric; Callejon, Kaka, Morata; Benzema