Arsene Wenger is set to rest a number of first-team stars for their clash against Sheffield Wednesday on Tuesday Getty

Arsenal are preparing to face Sheffield Wednesday in the fourth round of the Capital One Cup on Tuesday night (27 October) at Hillsborough with Arsene Wenger ready to make a number of changes to his first-team squad. The French manager is set to rest key players for the clash against the Owls due to fears of burnout after a hectic Premier League and Champions League schedule.

"It is a perfect week [on beating Bayern and Everton] and it is not easy to have that. The only negative is that we lost some players through injury during the week, but I will have to rest some players Tuesday night against Sheffield. I think for some players it will be one game too many for them," Wenger said, as quoted on Arsenal's official site.

The north London club trained ahead of their trip to Yorkshire on Monday, and various first-team regulars were missing in the session, with Wenger promoting a host of youth team players to the first-team. Apart from the young Gunners, fringe players are set to be given a chance with Mathieu Debuchy, Kieran Gibbs, Calum Chambers and Joel Campbell all expected to start the fourth round clash.

The 66-year-old manager has urged the players to grab their chance and prove that they are also capable of making the squad successful without the likes of Alexis Sanchez, Mesut Ozil and Santi Cazorla being in the team. He believes that every player in the squad needs to be prepared when the chance arrives.

"We want the players who come in to the team to show they are able to make the squad successful, and do absolutely everything to help us win," the Arsenal manager said, as quoted by the Mirror.

"That's the job of a footballer. When you get the chance, you have to be ready," the Frenchman added.