Murray suffered an injury setback on his pelvis and won't be making a dream comeback in Melbourne.
The Spaniard is one Grand Slam away from levelling Federer's tally of 20 titles.
The duo will play a charity match in front of 48,000 people in Cape Town
Murray was earlier rested for Britain's group match against Kazakhstan
The 32-year-old said he tried to put on a "brave face" for his children but his wife Kim Sears saw right through his struggle and stood by him.
Great Britain won their match against the Netherlands at the World Cup of Tennis
The Davis Cup Finals will now be played in a World Cup format with 18 national teams competing for glory
Nadal will finish the year as the World Number One after Djokovic lost to Federer
Nadal leads Djokovic with 640 points in their race to finish as the year-end World Number One
Zverev defeated Nadal 6-2, 6-4 in the Nitto ATP Finals in London
Nadal has never won the ATP Finals title while Djokovic won it five times
The Spaniard suffered an abdominal injury while arming up for the semi-final against Shapovalov.
Nadal advanced to the quarterfinals of the Paris Masters after beating Wawrinka 6-4, 6-4
The World number 10 defeated the world number one 3-6, 6-3, 6-4
All Big Four tennis greats are now married after Nadal's wedding
Djokovic has won 16 Grand Slams. 4 less than Federer's 20. Nadal holds 19.
Kyrgios has been offered a probation period of six months, within which he must improve his behaviour
During a live event, the comedy duo said that Osaka is over-sunburned
Murray came back from a hip surgery in January and has slowly been getting back into competition
This is Team Europe's third consecutive Laver Cup title. Nadal stepped back because of an injury.
Team Europe will be counting heavily on Roger Federer and Rafael Nadal to secure early victories for Team Europe on Day 3 of the Rod Laver Cup.
Nadal now has 19 Grand Slams to his name. He may soon catch Federer's 20 Grand Slam record.
The women's singles title went to the Canadian, to the disappointment of most of the crowd in Arthur Ashe Stadium.
Medvedev will be chasing his first Grand Slam title against one of the toughest possible opponents.
The Women's Singles Final will take place on Saturday in Flushing Meadows, New York
The Spanish icon is now two steps away from his fourth US Open title
A Federer-Nadal Final is no longer on the cards, as the World no. 78 creates history at Flushing Meadows
Djokovic eyes legendary feats in the current tennis season despite shocking US Open exit
Australian professional tennis player Nick Kyrgios has been slapped with a fine and might face a ban after calling ATP "pretty corrupt".
The Swiss legend dropped his opening set before stepping up his game to crush his opponent in the next three sets.