The Potters have taken just one point from their opening three games of the new Premier League campaign but sought to address that poor start with the signings of Netherlands defender Bruno Martins Indi, signed on loan from Porto, and Wilfried Bony on loan from Manchester City.
With No1 goalkeeper Jack Butland recovering from ankle surgery, the club also brought in Lee Grant from Derby County on another loan deal, with the 33-year-old expected to challenge Shay Given for a role in the first-team.
"They are definitely in my thoughts," Hughes told reporters when asked if his new signings were ready to make their debuts. "Both of them [Martins Indi and Bony) and Lee Grant, they've all trained really well. So they are in my thoughts.
"Clearly some haven't had a great deal of game time so that will be factored in, but if I decide to play any of them, I'll have no qualms about that, they are up to speed. They should be okay."
Bony's presence up front could be required immediately with Stoke having scored just one goal from open play this season. Mame Biram Diouf, who led the Potters' attack in each of those games, has also returned from international duty with Senegal with an injury, one Hughes expects will rule him out for the visit of Spurs.
"Jakob [Haugaard] has an ankle problem. Mame's returned with a slight issue; the likelihood is that he won't be available."
Xherdan Shaqiri is also set to miss Saturday's clash. "He still has a slight problem with his calf; he had different treatment this week to try loosen it. He responded well but won't be involved on Saturday."