Chelsea Handler broke down on TV as she opened up about Hillary Clinton's presidential defeat.

The comedian, who has been vocal in expressing her contempt for President-elect Donald Trump throughout the presidential race, struggled to fight tears as she discussed the election result on her Netflix talk show on Wednesday (9 November) night.

She revealed that, following the announcement that Trump had been voted President, she had planned to flee the country.

"I want to move to Spain," she explained. "I really, really want to move to Spain right now. Everyone in my office is like, ''you have a responsibility, you have a voice and you need to use it and you have to be here'."

Enlisting Senator Barbara Boxer on the show to help make sense of the results, Handler said that if Hillary Clinton made it through her concession speech without crying, she would refrain from crying too, however, moments later, she broke down.

"Sorry, I hate f*****g crying on camera,"' she said, visibly fighting back tears.

Handler commented that Trump should have been disqualified from running for president for the language he used during his bitter campaign against Clinton.

Composing herself in a video on her Instagram account, she urged women not to give up the fight for equality.

"I know as a woman, it feels so sexist (that Trump won)," she said. "I guess the message I went to get out is not to give up. Because this is so important. It's easy to throw in the towel," she added.

TV talk show host Seth Meyers shared her sentiment and was also moved to tears throughout his opening monologue as he expressed his fears for future generations.

"I do really feel for the parents who had to explain this to their kids this morning. Especially parents with daughters because a lot of them like me probably thought Hillary would be our first woman president," he explained.

"But she won't be. But that does mean - that does mean that someone's daughter is out there right now who will one day have that title. Maybe you're a woman who is currently a senator. Maybe you're still in college.

"But good news to our first woman president whoever you are, where ever you are, you may have been rooting for Hillary but now you can still be the first woman president and first is so much better than second."

Addressing the woman who will one day be the first female president of the US, Meyers said: "I hope I live to see your inauguration. And I hope my mom does too. She was really excited yesterday and I was really sad for her."

The news of Trump's presidential win sent shockwaves through the entertainment world. Stars such as Miley Cyrus, Madonna and Lady Gaga have spoken publicly of their dismay at the election result.