Outspoken TV host Chelsea Handler has waded into the public discussion about Brad Pitt and Angelina Jolie's divorce. The A list power couple made headlines after it was announced on Tuesday (20 September) that they are to split after 12 years together and two years of marriage.

Jolie filed for divorce citing 'irreconcilable differences' and is seeking full custody of their six children.

The Twitterverse went to town in a chorus of tweets about karma and an explosion of memes in honour of the once spurned wife of Pitt, Jennifer Aniston.

Handler, who is one of Aniston's closest friend's couldn't help but stand up for her bestie in the wake of the news that Brangelina is no more. On her Netflix show the comic featured a segment about the news of the Hollywood golden couple's split in which she slammed Brad Pitt for getting involved with Jolie. Pulling no punches she described the Maleficent actress as 'a f***ing lunatic'

Responding to claims that Jolie filed for divorce because she had enough of Brad Pitt's alleged drinking and use of weed, Handler said: "There are rumors that part of the problem was that Brad was allegedly drinking and smoking too much weed. I wonder why he would need to self-medicate.

"Maybe because he could have been spending the last 12 years at Lake Como hanging out with George Clooney and Matt Damon, instead of being stuck in a house with 85 kids speaking 15 different languages.

"Oh yeah, because he married a f***ing lunatic, that's why," she added.

The TV personality couldn't help herself as she cracked a joke at the couple's expense on Twitter. "Angelina Jolie has filed for divorce from Brad Pitt... he wants the China; she wants Pax and Maddox," she quipped.

The 41-year-old acknowledged the need for privacy for the family and promised she wouldn't talk about their split again, at least not on TV.

Handler, who was among the guests at the Friends star's wedding last year to actor Justin Theroux was clearly demonstrating that she is Team Aniston all the way as she made the jibes at Jolie.

It's widely speculated that Jolie and Pitt fell in love on the set of Mr and Mrs. Smith while Pitt was still married to Aniston and the alleged affair was the reason for the break-up of the former couple's five-year marriage.

While Aniston has not commented on her ex-husband's divorce her team has spoken out to refute claims that her own marriage is in trouble, However, UsWeekly claimed the 47-year-old had reacted to the news during a discussion with a friend commenting: 'Yeah, that's karma for you!'

Meanwhile Pitt, who is said to have been blindsided by the divorce, has appealed to his wife to keep the split amicable for the sake of his kids. But with the A list stars' friends and rivals revelling in the fallout, the Brangelina circus is just beginning.