Manchester City and Sevilla fans clashed on the eve of their Champions League match two weeks after Spanish fans were attacked at a Manchester pub before the corresponding fixture.
Video footage showed fans fighting in the street and the sound of smashed bottles. Violence reportedly broke out at Irish bar O'Neill's when masked fans smashed their way in before groups fought in an area of El Arenal, Calle Adriano.
Eye witnesses said City fans were left bleeding following the incident, while reports from Spain confirmed that two City supporters had suffered only minor injuries.
The running battle comes two weeks after chairs, glasses and a bicycle were thrown during destructive scenes outside a Manchester pub when City played Sevilla. Greater Manchester Police were called to reports of fighting at Sinclair's Oyster Bar in Shambles Square when Polish supporters attacked Spaniards drinking there.
City face Sevilla in Tuesday night's (3 November) Group D match,having beaten the Spaniards 2-1 thanks to a Kevin de Bruyne 91st-minute winner. A point would leave City on course to progress to the knock-out stages of Europe's premier tournament.