A F-16 fighter jet and a smaller plane collided in a fireball above a historic plantation in South Carolina, a witness has told local news outlets.

The Federal Aviation Administration confirmed the midair collision of a F-16 military jet and Cessna 150 private aircraft over Berkeley County to The Post and Courier, Charleston South Carolina's largest newspaper.

Emergency service radios reported one of the planes was carrying hydrazine, a colourless highly flammable liquid.

The US Air Force fire department is on the scene along with an Air Force official. Emergency services found the downed F-16 pilot and are transporting him to the hospital.

The crash site of the jet was in a remote woodlot on the plantation property. Local police dive teams accessed the second crash site in a nearby river.

The pilot and passenger in the Cessna have been pronounced dead.

Fire news source SConFire.com initially reported a "plane collision" and "multiple" emergency service vehicles heading to Lewisfield Plantation near Moncks Corner, Berkeley County near Charleston in South Carolina.

Michael Mule, a Berkeley County spokesperson, confirmed to ABC News 4 that a plane had crashed.

Images from the scene emerging on social media appear to show part of a military aircraft engine that almost fell directly on a camper trailer.

Reports from witnesses say the F-16 and Cessna collided, which resulted in a "ball of fire in the air" explosion. Flown by the Air Force, the F-16 Fighting Falcon is a single-engine fighter jet developed by General Dynamics. Fire crews have cordoned off an area near the crash.