Tottenham Hotspur will be without Toby Alderweireld, Erik Lamela and Ben Davies for their clash with West Ham United on Saturday (19 November), with doubts lingering over the fitness of Dele Alli.
Alderweireld has missed Tottenham's last six games due to a knee injury suffered in the 1-1 draw with West Brom on 15 August. Spurs boss Mauricio Pochettino initially played down the severity of the knock but the Belgium international is now set to miss a second London derby in a row, having also sat out of the club's 1-1 draw with Arsenal prior to the international break.
Lamela, meanwhile, has not featured since the goalless draw with Bournemouth on 22 October due to a persistent hip problem, while Dele Alli also suffered a knee injury in training the day before Tottenham's clash with Arsenal.
The north London side initially predicted the 20-year-old midfielder would be sidelined for a "few weeks," with the visit of Slaven Bilic's side now likely to come too soon for him.
Davies withdrew from the Wales squad ahead of their World Cup qualifier against Serbia due to an ankle problem, later revealing he did not expect to return to full first-team training for at least two weeks.
Pochettino confirmed the rest of his squad is available for selection, however, ending fitness concerns over Christian Eriksen, Mousa Dembele, Vincent Janssen and Victor Wanyama in the process.
There was concern for Eriksen when he was ruled out of Denmark's friendly with Czech Republic on Tuesday, having picked up a minor knock after scoring twice in a World Cup qualifier against Kazakhstan four days earlier. Dembele also returned to north London ahead of schedule during the round of international fixtures, after being ruled out of Belgium's qualifier against Estonia with what Roberto Martinez referred to as a "soft-tissue problem".
Summer signing Janssen was another to return to the capital battered and bruised after a collision with Belgium goalkeeper Simon Mignolet during Netherlands' friendly international fixture on 9 November in Amsterdam.
The 22-year-old striker lost 20 minutes of his memory, according to Dutch national team coach Danny Blind. There was also concern for Wanyama when he was taken off in the second half of Kenya's qualifier against Liberia, but the quartet are all in contention to feature on Saturday evening.
Pochettino has also confirmed Harry Kane is nearing full-fitness after his lengthy layoff. After enjoying a goal-scoring return to the first-team in the north London derby following his ankle injury, the 22-year-old was an unused substitute in England's comfortable 3-0 win over Scotland last Friday and was released from the squad before Tuesday's 2-2 draw with Spain.