Arsenal will finally have Aaron Ramsey available again for Saturday's (29 October) Premier League clash with Sunderland but Theo Walcott, Santi Cazorla and Nacho Monreal will all undergo late tests.
Ramsey has not played since the opening day of the season against Liverpool when he limped off with a hamstring injury. The Wales international has undergone a "second pre-season" with Wenger cautious about re-introducing him to the team. But the Gunners boss now feels his midfielder is ready for selection again.
Olivier Giroud meanwhile, who has had his own fitness problems this season, returned to the squad for Tuesday's EFL Cup fourth-round victory over Reading.
Speaking at a press conference ahead of Saturday's trip to the Stadium of Light, Wenger said: "They [Ramsey and Giroud] are back available for selection. I have to be cautious, especially with Ramsey, as he has not played at all this season and has had just one week [training] with the team."
Santi Cazorla could still be absent, however. The Spain international suffered an Achilles injury in the Champions League victory over Ludogorets and missed last weekend's draw with Middlesbrough as a result.
Walcott meanwhile has picked up a "slight hamstring problem", according to Wenger, while Monreal has "a little muscle tightness".
As reported by IBTimes UK on Thursday, Lucas Perez is the latest Arsenal player to join the injured list. The 27-year-old suffered an ankle ligament injury during the victory over Reading with Wenger confirming on Friday morning he will be without his summer signing for "six to eight weeks".
Perez limped off following a heavy challenge from Reading's Danzell Gravenberch and Wenger admitted his frustration over the incident, feeling it was a "deliberate kick" that injured his player.
"It's frustrating because he [Perez] worked hard to get there [into the starting XI]. He is frustrated, absolutely gutted, because it's an injury from nowhere, a stupid one, a deliberate kick.
"[The kick], it was not needed, it was a frustrated reaction from the player, he had no chance to get the ball. But we have to deal with that."