The Colombian duo started their time in English football in the summer of 2014 after the 'keeper joined Arsenal for around £3m, while the striker moved on loan to Old Trafford from Monaco on deadline day.
Ospina started the season at the Emirates Stadium as Wojciech Szczęsny's back-up but has impressed in the number one role since the Polish 'keeper reportedly smoked in the showers following the New Year's Day loss at Southampton.
Meanwhile, after overcoming an injury earlier in the campaign, Falcao has earned a regular spot in United manager Louis van Gaal's starting line-up. However, the Colombian striker is failing to make the impact expected at Old Trafford.
Having garnered a reputation as one of the best forwards in the world, during his spells at Porto, Atletico Madrid and Monaco, Falcao has only scored four goals in 16 Premier League appearances, 11 of them playing as a starter.
Ospina has come out in defence of his compatriot and claims it is only a matter of time before the striker discovers his best form for Manchester United.
"Falcao is very strong player. He is going to overcome the situation and he will prove his worth. No one can doubt about it. As soon as he gets the continuity he needs he will demonstrate his talent. He is a great person and he deserves it," Ospina said during an interview with Deportes RCN.
After an impressive 2014 World Cup, the Colombian players got the big European clubs to sit up and take note.
While James Rodriguez joined Real Madrid for around £63m, while Ospina, Falcao and Aston Villa midfielder Carlo Sanchez joined the Premier League.
Now Juan Cuadrado has followed suit with his move to Chelsea during the January transfer window.
Asked about that, Ospina said: "I'm happy. Colombia are going through a very good time. Everyone is taking advantage of the opportunities; we must keep working and open the door for many more Colombians to come to this great league."